URIC ACID SODIUM SALT Chemical Properties

storage temp. 

Store at -20°C

solubility 

1 M NaOH: 25 mg/ml

form 

Solution may appear as a slightly hazy suspension.

color 

Liquid

Stability:

Stable.

CAS DataBase Reference

1198-77-2

EPA Substance Registry System

1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-, monosodium salt (1198-77-2)

Safety Information

WGK Germany 

3

RTECS 

YU7062000

MSDS

• Language:English Provider:SigmaAldrich

URIC ACID SODIUM SALT Usage And Synthesis

Description

Uric acid is a ubiquitous end product of purine metabolism in humans that is mainly excreted in urine, whereas in other mammals it is further metabolized to allantoin by uricase. The final two steps in its production are catalyzed by xanthine oxidase, which generates superoxide. Uric acid acts as a potent peroxynitrite scavenger and antioxidant. However, high levels of serum uric acid (>120 μg/ml), termed hyperuricemia, are associated with gout, kidney stones, metabolic syndrome, hypertension, renal disease, and cardiovascular disease. Uric acid in the form of monosodium urate crystals has been proposed to trigger interleukin-1β-mediated inflammation by activating the NOD-like receptor protein 3 inflammasome.

Chemical Properties

solid

Uses

Uric acid sodium salt has been used in isotonic solution of NaCl dose titration study. It has been used as a suspension in NaCl for intra-articular administration to experimental animals to induce synovitis.

Biochem/physiol Actions

Sodium urate is the sodium salt of uric acid. In gout, it is observed in synovial fluid. Sodium urate has been shown to precipitate calcium oxalate from urine. It is also known to reverse the inhibitory effects of reactive oxygen and nitrogen metabolites on gelatinase A activity. Excess sodium urate in soft tissues results in a condition referred to as tophi.

Safety Profile

Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

storage

+4°C

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