6-Bromo-2-chlorobenzothiazole Chemical Properties

Melting point:

99-103 °C

Boiling point:

157°C/18mmHg(lit.)

Density 

1.849±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Toluene

form 

powder to crystal

pka

-0.87±0.10(Predicted)

color 

White to Orange to Green

CAS DataBase Reference

80945-86-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36

RIDADR 

UN 2811

WGK Germany 

3

HazardClass 

IRRITANT

PackingGroup 

Ⅲ

HS Code 

29342000

6-Bromo-2-chlorobenzothiazole Usage And Synthesis

Chemical Properties

White solid

Uses

Starting material in a synthesis of benzothiazole dimers with high binding affinity to β-amyloid fibrils.

Synthesis

General procedure for the synthesis of 6-bromo-2-chlorobenzothiazole from 6-bromo-2-benzothiazolone: 6-bromo-2-benzothiazolone (500 mg, 2.2 mmol) was dissolved in phosphorus trichloride (5 mL) and the reaction was carried out at reflux for 18 hours. After completion of the reaction, the reaction mixture was slowly poured into ice water. The pH of the mixture was adjusted to 9 with ammonia to neutralize the reaction. The resulting solid product was collected by filtration, washed with water and dried under vacuum to afford 6-bromo-2-chlorobenzothiazole (450 mg, 83% yield).

References

[1] Patent: WO2007/146066, 2007, A2. Location in patent: Page/Page column 88-89
[2] Patent: US2015/368278, 2015, A1. Location in patent: Paragraph 1050

6-Bromo-2-chlorobenzothiazole(80945-86-4)Related Product Information

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