DICLOFENAC-D4 Chemical Properties

Melting point:

157-159°C

storage temp. 

-20°C Freezer

solubility 

DMSO: 35 mg/ml,Ethanol: 35 mg/ml,PBS (pH 7.2): 6 mg/ml

form 

A solid

color 

White to off-white

Water Solubility 

Water: 50 mg/ml

CAS DataBase Reference

153466-65-0

DICLOFENAC-D4 Usage And Synthesis

Description

Diclofenac-d₄ is intended for use as an internal standard for the quantification of diclofenac (Item Nos. 70680 | 22983) by GC- or LC-MS. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC₅₀s = 0.9-2.7 and 1.5-20 μM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester and diclofenac amide . Diclofenac inhibits release of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) induced by A23187 in isolated rat peritoneal neutrophils and macrophages (IC₅₀s = 60 and 10 μM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

Chemical Properties

Off-White Crystalline Solid

Uses

Labeled Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. 92% overall isotopic purity. A representative lot was 75% d4, 23% d3 and 2 % d2

Uses

Labelled Diclofenac is a known nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.

Uses

Labelled Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.

References

[1] O LANEUVILLE. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.[J]. Journal of Pharmacology and Experimental Therapeutics, 1994, 271 2: 927-934.
[2] SHABBIR LOBO. Evaluation of diclofenac prodrugs for enhancing transdermal delivery.[J]. Drug Development and Industrial Pharmacy, 2014, 40 3: 425-432. DOI: 10.3109/03639045.2013.767828
[3] JEAN LEANDRO DOS SANTOS. Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect.[J]. International Journal of Molecular Sciences, 2012, 13 11: 15305-15320. DOI: 10.3390/ijms131115305
[4] HIMANSHU V. KOTHARI  Edmond C K  Warren H Lee. An alternate mechanism for regulation of leukotriene production in leukocytes: studies with an anti-inflammatory drug, sodium diclofenac[J]. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987, 921 3: Pages 502-511. DOI: 10.1016/0005-2760(87)90078-6
[5] PRIYANKA ARORA  Biswajit M. Design, development, physicochemical, and in vitro and in vivo evaluation of transdermal patches containing diclofenac diethylammonium salt[J]. Journal of pharmaceutical sciences, 2002, 91 9: 2076-2089. DOI: 10.1002/jps.10200

DICLOFENAC-D4(153466-65-0)Related Product Information

• DICLOFENAC ACID/[2-(2,6-DICHLORO-PHENYLAMINO)-PHENY]-ACETIC ACID,Diclofenac
• 2-ANILINOPHENYLACETIC ACID
• DICLOFENAC POTASSIUM /POTASSIUM [2-[(2,6-DICHLOROPHENYL)AMINO]PHENYL]ACETATE
• DICLOFENAC DIETHYLAMINE
• Diclofenac epolamine
• 2-(2-Bromo-6-chlorophenyl)amino)-phenylacetic acid sodium salt 95%
• 1-(2,6-Dichlorophenyl)indole-2,3-dione
• 2,4'-Dichlorobenzhydrol
• Diclofenac Acyl--D-glucuronide Allyl Ester
• 2,6-Dichloro-N-(4-chlorophenyl)-benzeneacetaMide
• 2-CHLORO-N-(2,6-DICHLOROPHENYL)ACETAMIDE
• 9H-Carbazole-1-acetic acid, 8-chloro-
• Diclofenac-13C6-Na hydrate (see Data Sheet)
• N-(2,6-dichlorophenyl)-N-phenylacetamide
• 2-(2,6-Dichloroanilino)-Phenylglyoxylic acid
• Diclofenac Impurity 7
• 2,6-DICHLORODIPHENYLAMINE
• 3'-hydroxy-4'-methoxydiclofenac