Basic information Safety Supplier Related

Acetoacetamide

Basic information Safety Supplier Related

Acetoacetamide Basic information

Product Name:
Acetoacetamide
Synonyms:
  • Acetyl acetomide
  • ACETOACETAMIDE PURUM
  • ACETIACETAMIDE
  • acetessigsaureamid
  • alpha-acetylacetamide
  • 3-Oxobutyramide
  • β-Oxobutanamide
  • Aids134414
CAS:
5977-14-0
MF:
C4H7NO2
MW:
101.1
EINECS:
227-774-4
Product Categories:
  • Amides
  • Carbonyl Compounds
  • Organic Building Blocks
  • Building Blocks
  • Carbonyl Compounds
  • Chemical Synthesis
  • Pharmaceutical Intermediates
  • Organic Building Blocks
Mol File:
5977-14-0.mol
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Acetoacetamide Chemical Properties

Melting point:
53-56 °C(lit.)
Boiling point:
271.0±23.0 °C(Predicted)
Density 
1.093±0.06 g/cm3(Predicted)
vapor pressure 
0.93Pa at 20℃
Flash point:
>230 °F
storage temp. 
Refrigerator
solubility 
water: soluble1g/10 mL, clear, colorless
form 
Crystalline Powder
pka
12.38±0.46(Predicted)
color 
white to yellowish
Water Solubility 
1000g/L at 20℃
BRN 
1560550
InChIKey
GCPWJFKTWGFEHH-UHFFFAOYSA-N
LogP
-1.4 at 23℃
CAS DataBase Reference
5977-14-0(CAS DataBase Reference)
EPA Substance Registry System
Butanamide, 3-oxo- (5977-14-0)
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Safety Information

WGK Germany 
1
RTECS 
EJ3667188

MSDS

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Acetoacetamide Usage And Synthesis

Chemical Properties

White to yellowish crystals

Uses

Acetoacetamide is used as intermediate for different organic syntheses, mainly organic dyestuffs. Product Data Sheet

Uses

Acetoacetamide was used in a study to assess the stability of artificial sweeteners- aspartame, acesulfame-K and binary sweetener blend of aspartame x acesulfame-K during storage. Acetoacetamide was also used in analysis of multiple sweeteners and their degradation products in lassi by HPLC.

Uses

Acetoacetamide is a β-keto amide commonly used in building heterocyclic systems. It can be used in synthesizing various N-substituted acetoacetamides, that are primary precursors for several organic dyes and pigments.

Definition

ChEBI: Acetoacetamide is a monocarboxylic acid amide of acetoacetic acid. It is functionally related to an acetoacetic acid.

General Description

Acetoacetamide is a degradation product of acesulfame-K, sweetener. Acetoacetamide undergoes alkaline hydrolysis to form salt of acetoacetic acid.

Flammability and Explosibility

Not classified

Purification Methods

Recrystallise the amide from CHCl3, or Me2CO/pet ether. It also crystallises from pyridine with 4mols of solvent. It is slightly soluble in H2O, EtOH and AcOH but is insoluble in Et2O. The phenylhydrazone has m 128o. [Kato Chem Pharm Bull Jpn 15 921 923 1967, Claisen & Meyer Chem Ber 35 583 1902, Beilstein 3 H 659, 3 I 231, 3 III 1204, 3 IV 1545.]

AcetoacetamideSupplier

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