4'-Methoxyacetoacetanilide Chemical Properties

Melting point:

115-118 °C

Boiling point:

346.25°C (rough estimate)

Density 

1.1878 (rough estimate)

vapor pressure 

0.001Pa at 20℃

refractive index 

1.5100 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

11.35±0.46(Predicted)

form 

Powder

color 

White to Blue

Water Solubility 

soluble

LogP

0.85 at 23℃ and pH8.3-8.6

CAS DataBase Reference

5437-98-9(CAS DataBase Reference)

NIST Chemistry Reference

Butanamide, 3-oxo-n-(4-methoxyphenyl)-(5437-98-9)

EPA Substance Registry System

Butanamide, N-(4-methoxyphenyl)-3-oxo- (5437-98-9)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

26-36/37/39

RTECS 

AK4598010

HS Code 

2924297099

MSDS

• Language:English Provider:4'-Methoxyacetoacetanilide
• Language:English Provider:ACROS

4'-Methoxyacetoacetanilide Usage And Synthesis

Chemical Properties

WHITE TO VERY SLIGHTLY YELLOW POWDER

Uses

N-(4-Methoxyphenyl)-3-oxobutanamide is an intermediate in the synthesis of Tafenoquine-d3 Succinate is the labelled analog of Tatenoquine (T004760), a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.

Synthesis Reference(s)

The Journal of Organic Chemistry, 11, p. 803, 1946 DOI: 10.1021/jo01176a024

4'-Methoxyacetoacetanilide(5437-98-9)Related Product Information

• p-Anisidine
• 2'-Chloroacetoacetanilide
• Acetylacetone
• Acetoacetamide
• p-Acetotoluidide
• m-Anisidine
• Acetanilide
• 2-BENZOYLACETANILIDE
• N-ACETYL-L-TYROSINE ETHYL ESTER
• 4-Aminoveratrole
• 4'-Aminoacetanilide
• 4-(Trifluoromethoxy)aniline
• 4'-Nitroacetanilide
• Acetazolamide
• 2,5-Dimethoxyacetoacetanilide
• N-(4-Methylphenyl)-3-oxobutanamide
• 4'-Chloroacetoacetanilide
• N-(Acetoacetyl)anthranilic acid