4-Hydroxypiperidine hydrochloride Chemical Properties

Melting point:

155-157 °C(lit.)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

methanol: soluble25mg/mL, clear, colorless

form 

powder to crystaline

color 

White to Orange to Green

Water Solubility 

very faint turbidity

BRN 

3908995

CAS DataBase Reference

5382-17-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

3

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich

4-Hydroxypiperidine hydrochloride Usage And Synthesis

Chemical Properties

White powder

Uses

4-Hydroxypiperidine, HCl

Uses

4-Hydroxypiperidine hydrochloride is suitable for use in the Ugi-multi component reaction (MCR) to study the use of miniaturised-synthesis and Total Analysis System (mSYNTAS) in solution phase synthesis and on-line analysis of Ugi-MCRs. It may be used in the synthesis of acetic acid-piperidine-4-yl ester.

General Description

4-Hydroxypiperidine hydrochloride is a piperidine derivative. The synthesis of 4-hydroxypiperidine has been reported. 4-Hydroxypiperidine participates in the synthesis of 4-(4′-hydroxypiperidino)-4-phenylcyclohexanol and 1-(4-hydroxypiperidino)cyclohexanecarbonitrile. 4-Hydroxypiperidine is the starting material for the synthesis of Sibrafiban and Lamifiban, two non-peptidefibrinogen receptor.

Synthesis

The general procedure for the synthesis of 4-hydroxypiperidine hydrochloride from N-Boc-4-hydroxypiperidine was as follows: tert-butyl 4-hydroxypiperidine-1-carboxylate (5 g, 24.84 mmol, 1.00 eq.) was mixed with a saturated HCl solution dissolved in 30 mL of 1,4-dioxane, and the reaction was stirred for 2 h at room temperature. Upon completion of the reaction, the mixture was concentrated in vacuum to afford 4-hydroxypiperidine hydrochloride (3.4 g, 99% yield) as an off-white solid.

References

[1] Patent: WO2015/52264, 2015, A1. Location in patent: Paragraph 0918; 0919
[2] Patent: WO2017/153520, 2017, A1. Location in patent: Page/Page column 50
[3] Patent: WO2016/34673, 2016, A1. Location in patent: Page/Page column 120

4-Hydroxypiperidine hydrochloride(5382-17-2)Related Product Information

• Topotecan hydrochloride
• 4-Hydroxyaniline hydrochloride
• 2,2,6,6-Tetramethyl-4-piperidinol
• Haloperidol
• DROPERIDOL
• 4-Cyanophenol
• Piperidine hydrochloride
• Diphenoxylate
• 3-HYDROXYPIPERIDINE HYDROCHLORIDE
• HOMATROPINE HYDROCHLORIDE
• STRYCHNINE HYDROCHLORIDE
• 4-(4-Chlorophenyl)piperidin-4-ol
• 4-[3-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINOL HYDROCHLORIDE
• Scopine hydrochloride
• lifibrate
• COCAINE HYDROCHLORIDE
• 4-Piperidone hydrochloride hydrate
• 1-BENZYL-4-CYANO-4-HYDROXYPIPERIDINE