protizinic acid
protizinic acid Basic information
- Product Name:
- protizinic acid
- Synonyms:
-
- 2-(7-Methoxy-10-methyl-10H-phenothiazin-2-yl)propionic acid
- 7-Methoxy-α,10-dimethyl-10H-phenothiazine-2-acetic acid
- ENC2374530
- Pirocrid
- protizinic acid
- Protizinic
- 10H-Phenothiazine-2-acetic acid, 7-methoxy-α,10-dimethyl-
- CAS:
- 13799-03-6
- MF:
- C17H17NO3S
- MW:
- 315.39
- EINECS:
- 237-453-0
- Mol File:
- 13799-03-6.mol
protizinic acid Chemical Properties
- Melting point:
- 124-125 °C
- Boiling point:
- 524.6±50.0 °C(Predicted)
- Density
- 1.285±0.06 g/cm3(Predicted)
- pka
- 4.14±0.10(Predicted)
protizinic acid Usage And Synthesis
Uses
Protizinic acid is an orally active non-steroidal antiinflammatory agent with antiinflammatory and antipyretic activity. Protizinic acid inhibits phospholipase A2 (PLA2) activity, and the IC50 value is 210 μM[1][2].
Definition
ChEBI: Protizinic acid is an organic molecular entity.
in vivo
In vivo leukokinin (LK) generation system using feline acute ischemia model, When 3 mg/kg Protizinic acid is injected twice intravenously to cats with acute cardiac ischemia, increased blood acid protease activity is inhibited and significant inhibitory action on the decrease of leukokininogen, the precursor of leukokinin, is observed[1].
Oral administration of 30 mg/kg of Protizinic acid significantly inhibits arachidonic acid-induced erythema in guinea pigs[2].
IC 50
PLA2: 210 μM (IC50)
References
[1] K Suzuki, et al. Effects of protizinic acid on leukokinin generation and its physiological action. Agents Actions. 1984 Jun;14(5-6):699-706. DOI:10.1007/BF01978911
[2] H Ohnishi, et al. Effects of protizinic acid on the prostaglandins system and the production of oxygen radicals. Nihon Yakurigaku Zasshi. 1982 Jun;79(6):561-9. PMID:6290356
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