metiazinic acid
metiazinic acid Basic information
- Product Name:
- metiazinic acid
- Synonyms:
-
- metiazinic acid
- Metiazinic
- (10-methyl-10H-phenothiazin-2-yl)acetic acid
- (10-METHYL2-PHENOTHIAZINYL)ACETICACID
- Ambrunate
- Metian
- Novartril
- RP 16091
- CAS:
- 13993-65-2
- MF:
- C15H13NO2S
- MW:
- 271.33
- EINECS:
- 2377950
- Mol File:
- 13993-65-2.mol
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metiazinic acid Chemical Properties
- Melting point:
- 146℃
- Boiling point:
- 482.6±44.0 °C(Predicted)
- Density
- 1.2237 (rough estimate)
- refractive index
- 1.7500 (estimate)
- pka
- 4.12±0.10(Predicted)
- Water Solubility
- 31mg/L(30 ºC)
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metiazinic acid Usage And Synthesis
Originator
Soripan,Specia,France,1970
Definition
ChEBI: Phenothiazine substituted at nitrogen by a methyl group and at C-2 by a carboxymethyl group.
Manufacturing Process
10-Methyl-3-acetylphenthiazine is prepared in accordance with G. Cauquil and A. Casadevall, Bull. Soc.Chim., p 768 (1955). (10-Methyl-3-phenthiazinyl)acetic acid (MP 146°C; 21.4 g) is prepared by Willgerodt's reaction (action of sulfur and morpholine, followed by hydrolysis) employing 10-methyl-3-acetylphenthiazine as starting material.
Therapeutic Function
Antiinflammatory
Trade name
Roimal (Kantoishi, Japan), Soripal (Torii, Japan).
Synthesis
Metiazinic acid is prepared via
the Willgerodt reaction (sulfur and morpholine)
from 2-acetyl-10-methylphenothiazine.
Dosage
Metiazinic acid has been beneficial to arthritis patients when given at a daily dose of 0.75 – 1.5 g/d.