treosulfan Chemical Properties

Melting point:

76-78 °C

Boiling point:

359.3°C (rough estimate)

Density 

1.305 (estimate)

refractive index 

1.5630 (estimate)

storage temp. 

Store at -20°C

solubility 

Acetone (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

pka

12.36±0.20(Predicted)

color 

Off-White to Pale Beige

CAS DataBase Reference

299-75-2

IARC

1 (Vol. 26, Sup 7, 100A) 2012

EPA Substance Registry System

Treosulfan (299-75-2)

Safety Information

RIDADR 

2811

HazardClass 

6.1(b)

PackingGroup 

III

Hazardous Substances Data

299-75-2(Hazardous Substances Data)

Toxicity

LDLo intravenous in dog: 222mg/kg

treosulfan Usage And Synthesis

Uses

Treosulfan is used as myeloablative agent in conditioning regimen prior to allogeneic hematopoietic stem cell transplantation (HSCT)??. It can also be an effective agent for conditioning children with inborn errors of immunity (IEI).

Definition

ChEBI: Treosulfan is a methanesulfonate ester.

General Description

Odorless white crystalline powder.

Air & Water Reactions

Water soluble. Slowly hydrolyzes: decomposes within 3 hours at pH 7.5 and 77°F. .

Fire Hazard

Flash point data for treosulfan are not available; however, treosulfan is probably combustible.

Clinical Use

Alkylating agent for ovarian cancer

Safety Profile

Confirmed carcinogen. Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits toxic fumes of SOx.

Metabolism

Treosulfan is a prodrug of a bifunctional alkylating agent, converted in vivo to epoxide compounds. Approximately 30
% of the substance is excreted unchanged in the urine within 24 hours, nearly 90
% of which is within the first 6 hours after administration.

treosulfan(299-75-2)Related Product Information

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