1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Chemical Properties

form 

Solid

color 

Off-white to pink

1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Usage And Synthesis

Description

WUN-98382 is a functionalized cereblon ligand for PROTAC? research and development. It incorporates an E3 ligase ligand plus an alkylC8 linker with a terminal amine ready for conjugation to a target protein ligand. WUN-98382 is Part of a range of functionalized tool molecules for PROTAC R&D. This product has no formal name.

Uses

Thalidomide-4-O-C8-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC 50

Cereblon

storage

Store at -20°C

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)(2636798-38-2)Related Product Information

• Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride
• Thalidomide-linker 14
• Thalidomide-O-amido-PEG4-azide
• Thalidomide-O-amido-PEG1-(C1-?PEG)2-C2-NH2
• N-(3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide Trifluoroacetate
• Thalidomide-O-amido-PEG1-N3
• Thalidomide-O-PEG4-amine hydrochloride
• Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 hydrochloride
• Thalidomide-O-amido-PEG6-azide
• Thalidomide-O-amido-PEG6-NH2 hydrochloride
• Thalidomide-Piperazine-PEG1-NH2 hydrochloride
• Thalidomide-O-PEG3-azide
• Thalidomide-O-PEG2-amine hydrochloride
• Thalidomide-O-amido-PEG5-azide
• Thalidomide-O-amido-PEG5-NH2 hydrochloride
• Thalidomide-O-C10-NH2 hydrochloride
• Thalidomide-O-PEG2-azide
• Thalidomide-O-amido-PEG2-azide