Thalidomide-O-amido-PEG4-azide Chemical Properties

storage temp. 

-20°C, sealed storage, away from moisture

form 

Solid

color 

White to off-white

Safety Information

HS Code 

2933998090

Thalidomide-O-amido-PEG4-azide Usage And Synthesis

Description

Thalidomide-O-amido-PEG4-azide is a PROTAC linker that is reactive with alkyne or DBCO, BCN attached molecule via click chemistry, PEG space increase compound solubility.

Uses

Thalidomide-O-amido-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Thalidomide-O-amido-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

Cereblon

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Thalidomide-O-amido-PEG4-azide(2411681-89-3)Related Product Information

• Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride
• Thalidomide-linker 14
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• E3 Ligase Ligand-Linker Conjugates 20
• E3 Ligase Ligand-Linker Conjugates 21
• E3 Ligase Ligand-Linker Conjugates 19
• Thalidomide-O-amido-C4-NH2 hydrochloride
• Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
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• Thalidomide-O-amido-C8-NH2 hydrochloride
• Thalidomide-O-amido-PEG1-(C1-?PEG)2-C2-NH2
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• E3 Ligase Ligand-Linker Conjugates 24 (TFA)
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