BAY 2666605
BAY 2666605 Basic information
- Product Name:
- BAY 2666605
- Synonyms:
-
- BAY 2666605
- anticancer effect,inhibit,BAY 2666605,orally active,PDE3A-SLFN12 Complex,Phosphodiesterase (PDE),BAY2666605,BAY-2666605,Inhibitor
- 2H-1,3,4-Oxadiazin-2-one, 5-[4'-fluoro-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3,6-dihydro-6-methyl-, (6S)-
- BAY 266605
- (S)-5-[4’-Fluoro-2-(trifluoromethyl)-4-biphenylyl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one
- (S)-5-[4’-Fluoro-2-(trifluoromethyl)-4-biphenylyl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one
- CAS:
- 2275774-60-0
- MF:
- C17H12F4N2O2
- MW:
- 352.28
- Mol File:
- 2275774-60-0.mol
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BAY 2666605 Chemical Properties
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- form
- Solid
- pka
- 9.07±0.60(Predicted)
- color
- White to off-white
- InChI
- InChI=1S/C17H12F4N2O2/c1-9-15(22-23-16(24)25-9)11-4-7-13(14(8-11)17(19,20)21)10-2-5-12(18)6-3-10/h2-9H,1H3,(H,23,24)/t9-/m0/s1
- InChIKey
- JNTJTCXFIXNXDV-VIFPVBQESA-N
- SMILES
- O1[C@@H](C)C(C2=CC=C(C3=CC=C(F)C=C3)C(C(F)(F)F)=C2)=NNC1=O
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BAY 2666605 Usage And Synthesis
Uses
BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer.
in vitro
BAY 2666605 has anticancer effects, potently inhibit brain cancer(especially glioma, more specifically glioblastoma, astrocytoma), breast cancer (especially ductal carcinoma and adenocarcinoma), cervical cancer, AML(especially erythroleucemia), lung cancer(especially NSCLC adenocarcinoma and SCLC), skin cancer(especially melanoma), oesophagus cancer (especially squamous cell carcinoma), ovarian cancer, (especially teratocarcinoma, adenocarcinoma), pancreas cancer and prostatic cancer.
BAY 2666605Supplier
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Shanghai XingMo Biotechnology Co., Ltd.
- Tel
- 13524779951
- 2075692521@qq.com
Chengdu DingDang Pharmaceutical Co., Ltd.
- Tel
- 028-86040038 13980902949;
- market@dingdangchem.com
Beijing Solarbio Science & Tecnology Co., Ltd.
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
Guangzhou Younan Technology Co., Ltd
- Tel
- 020-020-82000279 18988968278
- sales@ubiochem.com