Basic information Safety Supplier Related

BAY 2666605

Basic information Safety Supplier Related

BAY 2666605 Basic information

Product Name:
BAY 2666605
Synonyms:
  • BAY 2666605
  • anticancer effect,inhibit,BAY 2666605,orally active,PDE3A-SLFN12 Complex,Phosphodiesterase (PDE),BAY2666605,BAY-2666605,Inhibitor
  • 2H-1,3,4-Oxadiazin-2-one, 5-[4'-fluoro-2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-3,6-dihydro-6-methyl-, (6S)-
  • BAY 266605
  • (S)-5-[4’-Fluoro-2-(trifluoromethyl)-4-biphenylyl]-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one
  • BAY 2666605, 10 mM in DMSO
  • BAY 2666605 ，E1205
  • (S)-5-(4'-Fluoro-2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-6-methyl-3,6-dihydro-2H-1,3,4-oxadiazin-2-one
CAS:
2275774-60-0
MF:
C17H12F4N2O2
MW:
352.28
Mol File:
2275774-60-0.mol
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BAY 2666605 Chemical Properties

Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
form 
Solid
pka
9.07±0.60(Predicted)
color 
White to off-white
InChI
InChI=1S/C17H12F4N2O2/c1-9-15(22-23-16(24)25-9)11-4-7-13(14(8-11)17(19,20)21)10-2-5-12(18)6-3-10/h2-9H,1H3,(H,23,24)/t9-/m0/s1
InChIKey
JNTJTCXFIXNXDV-VIFPVBQESA-N
SMILES
O1[C@@H](C)C(C2=CC=C(C3=CC=C(F)C=C3)C(C(F)(F)F)=C2)=NNC1=O
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BAY 2666605 Usage And Synthesis

Uses

BAY 2666605 is an orally active PDE3A and PDE3B inhibitor with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 is a PDE3A-SLFN12 complex inducer.

in vitro

BAY 2666605 has anticancer effects, potently inhibit brain cancer(especially glioma, more specifically glioblastoma, astrocytoma), breast cancer (especially ductal carcinoma and adenocarcinoma), cervical cancer, AML(especially erythroleucemia), lung cancer(especially NSCLC adenocarcinoma and SCLC), skin cancer(especially melanoma), oesophagus cancer (especially squamous cell carcinoma), ovarian cancer, (especially teratocarcinoma, adenocarcinoma), pancreas cancer and prostatic cancer.

in vivo

BAY 2666605 (5 mg/kg; p.o; twice daily) teatment shows anti-tumor efficacy in murine xenotransplantation models of human cancer[1].

IC 50

PDE3A: 87 nM (IC50); PDE3B: 50 nM (IC50)

BAY 2666605Supplier

BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Shanghai XingMo Biotechnology Co., Ltd.
Tel
+86 13524779951; 13524779951
Email
2075692521@qq.com
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Chengdu DingDang Pharmaceutical Co., Ltd.
Tel
028-86040038 13980902949;
Email
market@dingdangchem.com
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