BAY-1125976. Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO:13.0(Max Conc. mg/mL);33.9(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);13.04(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.65(Max Conc. mM)

form 

A crystalline solid

color 

Light yellow to yellow

BAY-1125976. Usage And Synthesis

Description

BAY-1125976 is an allosteric inhibitor of Akt1 and -2 (IC₅₀s = 5.2 and 18 nM, respectively, in a time-resolved FRET assay). It is selective for Akt1 and -2 over Akt3 (IC₅₀ = 427 nM in the same assay) but does inhibit the activity of the receptor tyrosine kinases FLT1, -3, -4, and Mer by greater than 50% in a panel of 227 kinases at 1 μM. BAY-1125976 inhibits the proliferation of 23 cancer cell lines (IC₅₀s = 0.02-10 μM) and reduces tumor growth in KPL-4, MCF-7, and patient-derived xenograft (PDX) mouse models when administered at a dose of 50 mg/kg per day.

BAY-1125976.(1402608-02-9)Related Product Information

• BAY1895344 2HCl
• BAY-2402234
• BAY-885
• BAY-985
• BAY 1316957)
• BAY-1163877
• BAY1895344 HCl
• BAY-1895344
• Benzamide, N-[5-(3,5-dicyano-1,4-dihydro-1,2,6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethyl-
• BAY 2666605
• BAY 2416964