BAY-885
BAY-885 Basic information
- Product Name:
- BAY-885
- Synonyms:
-
- BAY-885
- [2-amino-4-(trifluoromethoxy)phenyl]-{4-[7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl]piperidin-1-yl}methanone
- Methanone, [2-amino-4-(trifluoromethoxy)phenyl][4-[7-(4-methyl-1-piperazinyl)pyrido[3,2-d]pyrimidin-4-yl]-1-piperidinyl]-
- BAY-885 USP/EP/BP
- BAY 885,ERK,inhibit,Extracellular signal regulated kinases,Inhibitor,BAY885,BAY-885
- CAS:
- 2307249-33-6
- MF:
- C25H28F3N7O2
- MW:
- 515.53
- Mol File:
- 2307249-33-6.mol
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BAY-885 Chemical Properties
- Boiling point:
- 685.0±55.0 °C(Predicted)
- Density
- 1.362±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO:23.33(Max Conc. mg/mL);45.25(Max Conc. mM)
Ethanol:8.0(Max Conc. mg/mL);15.52(Max Conc. mM) - form
- A solid
- pka
- 7.06±0.42(Predicted)
- color
- White to light yellow
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BAY-885 Usage And Synthesis
Use
BAY-885 is a highly potent and selective ERK5 inhibitor.
In vitro
BAY-885 shows potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM) and has no effects on a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM), thereby ruling out potential effects as a general inhibitor of transcription or translation.
BAY-885Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
ShangHai Biochempartner Co.,Ltd
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- 17754423994 17754423994
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Shanghai Rechem science Co., Ltd.
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- 21-31433387 15618786686
- sales@rechemscience.com
Beijing Solarbio Science & Tecnology Co., Ltd.
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- 010-50973130 4009686088
- 3193328036@qq.com
Chuzhou KeMail Chemical Technology Co., Ltd
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- 0550-5196001 15000891977
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