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BAY-885

Use In vitro
Product Name
BAY-885
CAS No.
2307249-33-6
Chemical Name
BAY-885
Synonyms
BAY-885;BAY-885 USP/EP/BP;BAY885, 10 mM in DMSO;BAY 885,ERK,inhibit,Extracellular signal regulated kinases,Inhibitor,BAY885,BAY-885;[2-amino-4-(trifluoromethoxy)phenyl]-{4-[7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl]piperidin-1-yl}methanone;Methanone, [2-amino-4-(trifluoromethoxy)phenyl][4-[7-(4-methyl-1-piperazinyl)pyrido[3,2-d]pyrimidin-4-yl]-1-piperidinyl]-
CBNumber
CB64667614
Molecular Formula
C25H28F3N7O2
Formula Weight
515.53
MOL File
2307249-33-6.mol
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BAY-885 Property

Boiling point:
685.0±55.0 °C(Predicted)
Density 
1.362±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO:23.33(Max Conc. mg/mL);45.25(Max Conc. mM)
Ethanol:8.0(Max Conc. mg/mL);15.52(Max Conc. mM)
form 
A solid
pka
7.06±0.42(Predicted)
color 
White to light yellow
InChI
1S/C25H28F3N7O2/c1-33-8-10-34(11-9-33)17-12-21-23(30-14-17)22(32-15-31-21)16-4-6-35(7-5-16)24(36)19-3-2-18(13-20(19)29)37-25(26,27)28/h2-3,12-16H,4-11,29H2,1H3
InChIKey
QXURFIGBRGWPQD-UHFFFAOYSA-N
SMILES
O=C(N1CCC(CC1)C2=C3C(C=C(C=N3)N4CCN(CC4)C)=NC=N2)C5=CC=C(C=C5N)OC(F)(F)F
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0043294
Product name
BAY885
Purity
99.15%
Packaging
5mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0043294
Product name
BAY885
Purity
99.15%
Packaging
10mg
Price
$750
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611265
Product name
BAY-885
Purity
>98%
Packaging
10mg
Price
$1208.7
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611265
Product name
BAY-885
Purity
>98%
Packaging
25mg
Price
$1802
Updated
2021/12/16
ChemScene
Product number
CS-0043294
Product name
BAY885
Purity
99.15%
Packaging
50mg
Price
$2600
Updated
2021/12/16
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BAY-885 Chemical Properties,Usage,Production

Use

BAY-885 is a highly potent and selective ERK5 inhibitor.

In vitro

BAY-885 shows potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM) and has no effects on a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM), thereby ruling out potential effects as a general inhibitor of transcription or translation.

Uses

BAY885 is a highly potent and selective ERK5 inhibitor with an IC50 of 35 nM. BAY885 shows weak inhibition on others kinases[1].

Biological Activity

BAY-885 is an ATP site-targeting, potent and selective ERK5 (BMK1, MAPK7) inhibitor (IC50 = 35 nM with 250 μM ATP; % inhibition at 1 μM = 62/r at Fer, 58/human EphB3, 43/human EphA5, =20/355 kinases) with no BRD4 affinity (20 μM), nor inhibitory potency toward hERG (10 μM) and CYP enzymes (20 μM; CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A4). BAY-885 potently inhibits 100 ng/mL EGF-induced, ERK5-dependent MEF2 activity (IC50 = 120 nM; SN12C-MEF2-luc reporter assay).

IC 50

ERK5: 35 nM (IC50)

References

[1] Nguyen D, et al. Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. J Med Chem. 2019 Jan 24;62(2):928-940. DOI:10.1021/acs.jmedchem.8b01606

BAY-885 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-885 Suppliers

China 44 United States 7 Global 51
BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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12952
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
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4800
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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Shanghai Rechem science Co., Ltd.
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021-31433387 15618786686
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QQ:1369748377
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sales@rechemscience.com
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China
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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Beijing Solarbio Science & Tecnology Co., Ltd.
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010-50973130 18101056239
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3193328036@qq.com
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China
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Chuzhou KeMail Chemical Technology Co., Ltd
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0550-5196001 15000891977
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0550-5196001
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wj520wjxby@126.com
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China
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Syntechem Co.,Ltd.
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519-88298820 15861130028
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86-519-83850735
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info@syntechem.com
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China
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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liming@bio-fount.com
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China
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9729
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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32470
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2307249-33-6, BAY-885Related Search:

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  • BAY-885
  • [2-amino-4-(trifluoromethoxy)phenyl]-{4-[7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl]piperidin-1-yl}methanone
  • Methanone, [2-amino-4-(trifluoromethoxy)phenyl][4-[7-(4-methyl-1-piperazinyl)pyrido[3,2-d]pyrimidin-4-yl]-1-piperidinyl]-
  • BAY-885 USP/EP/BP
  • BAY 885,ERK,inhibit,Extracellular signal regulated kinases,Inhibitor,BAY885,BAY-885
  • BAY885, 10 mM in DMSO
  • 2307249-33-6
  • C25H28F3N7O2