ChemicalBook > CAS DataBase List > BAY-985

BAY-985

Product Name
BAY-985
CAS No.
2409479-29-2
Chemical Name
BAY-985
Synonyms
BAY-985;BAY-985, 10 mM in DMSO;BAY-985,IKK,BAY985,IκB kinase,melanoma,IKKε,TBK1,inhibit,I kappa B kinase,Inhibitor,BAY 985,antitumor;1-Propanone, 1-[4-[(1R)-1-[2-[[6-[6-(dimethylamino)-4-pyrimidinyl]-1H-benzimidazol-2-yl]amino]-4-pyridinyl]ethyl]-1-piperazinyl]-3,3,3-trifluoro-;(R)-1-(4-(1-(2-((6-(6-(Dimethylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-yl)amino)pyridin-4-yl)ethyl)piperazin-1-yl)-3,3,3-trifluoropropan-1-one
CBNumber
CB55839640
Molecular Formula
C27H30F3N9O
Formula Weight
553.58
MOL File
2409479-29-2.mol
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BAY-985 Property

Boiling point:
753.3±70.0 °C(Predicted)
Density 
1.373±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 50 mg/mL (90.32 mM)
form 
A solid
pka
10.06±0.10(Predicted)
color 
Light yellow to yellow
InChIKey
HZRJHVDNTDBTOZ-QGZVFWFLSA-N
SMILES
C(N1CCN([C@@H](C2C=CN=C(NC3NC4=CC(C5C=C(N(C)C)N=CN=5)=CC=C4N=3)C=2)C)CC1)(=O)CC(F)(F)F
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0112070
Product name
BAY-985
Purity
99.87%
Packaging
5mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0112070
Product name
BAY-985
Purity
99.87%
Packaging
10mg
Price
$880
Updated
2021/12/16
ChemScene
Product number
CS-0112070
Product name
BAY-985
Purity
99.87%
Packaging
50mg
Price
$1950
Updated
2021/12/16
DC Chemicals
Product number
012784
Product name
BAY-985
Packaging
002
Price
$1500
Updated
2021/12/16
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BAY-985 Chemical Properties,Usage,Production

Uses

BAY-985 is a highly potent, orally active and selective ATP-competitive dual inhibitor of TBK1 and IKKε with IC50s of 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε, respectively. Antitumor efficacy[1].

Biological Activity

BAY-985 is a potent and highly selective TBK1/IKKε inhibitor. It is highly potent against TBK1 (IC50 = 2 nM, low ATP assay; 30 nM, high ATP assay) and IKKε (IC50 = 2 nM) and also in mechanocellular phosphorylation of interferon regulatory factor 3 (pIRF3) assays High potency (IC50 = 74 nM) and anti-proliferative effect on SK-MEL-2 cells (IC50 = 900 nM).

in vitro

BAY-985 inhibits FLT3, RSK4, DRAK1, and ULK1 with IC 50 s of 123, 276, 311, and 7930 nM, respectively.
BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 (IRF3) with an IC 50 of 74 nM.
BAY-985 is active in cellular mechanistic assay and shows anti-proliferative activity in a few cancer cells lines with IC 50 s of 900 and 7260 nM for SK-MEL2 (NRAS and TP53 mutated) and ACHN (CDKN2A mutated) cells, respectively.

Cell Proliferation Assay

td>
Cell Line: ACHN and SK-MEL-2 cell lines
Concentration:
Incubation Time: 96 hours
Result: Inhibited proliferation i n SK-MEL2 and ACHN cells with IC 50 s of 900 and 7260 nM, respectively.

in vivo

BAY-985 (200 mg/kg; po; bid; 111 days) results in weak antitumor efficacy.
BAY-985 shows high clearance (CL b = 4.0 L/h/kg, ca. 95% hepatic extraction), large volume of distribution at steady state (V ss =2.9 L/kg) and a short terminal half-life (t 1 /2 =0.79 h).

Animal Model: Female NMRI nude mice bearing SK-MEL-2 human melanoma xenograft model
Dosage: 200 mg/kg
Administration: Applied po; twice daily (bid) continuously 111 days
Result: Treatment resulted in weak antitumor efficacy with a T/C tumor weight ratio of 0.6.
The treatment was well tolerated, with a maximum body weight loss of less than 10%.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> TBK1
(in high ATP assay)
TargetValue
TBK1
(in low ATP assay)		 2 nM
IKKε
(Cell-free assay)		 2 nM
30 nM
pIRF3
(Cell-free assay)		 74 nM

IC 50

TBK1: 2 nM (IC50, low ATP); TBK1: 30 nM (IC50, high ATP); IKKε: 2 nM (IC50)

References

[1] Lefranc J, et al. Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor. J Med Chem. 2020 Jan 10. DOI:10.1021/acs.jmedchem.9b01460

BAY-985 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-985 Suppliers

China 49 United States 5 Global 54
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
15000803246 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
424
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Twochem Co.Ltd
Tel
021-021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
304
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1944
Advantage
55
Shanghai Changyu Medical Technology Co. Ltd.
Tel
+86-13301875428
Email
sales@changyuhe.com
Country
China
ProdList
311
Advantage
58
Shijiazhuang Leather Bureau Chemical Technology Co., Ltd.
Tel
13020863400
Email
liaoy124@163.com
Country
China
ProdList
293
Advantage
58

2409479-29-2, BAY-985Related Search:

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  • BAY-985
  • 1-Propanone, 1-[4-[(1R)-1-[2-[[6-[6-(dimethylamino)-4-pyrimidinyl]-1H-benzimidazol-2-yl]amino]-4-pyridinyl]ethyl]-1-piperazinyl]-3,3,3-trifluoro-
  • BAY-985,IKK,BAY985,IκB kinase,melanoma,IKKε,TBK1,inhibit,I kappa B kinase,Inhibitor,BAY 985,antitumor
  • (R)-1-(4-(1-(2-((6-(6-(Dimethylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-yl)amino)pyridin-4-yl)ethyl)piperazin-1-yl)-3,3,3-trifluoropropan-1-one
  • BAY-985, 10 mM in DMSO
  • 2409479-29-2
  • C27H30F3N9O