BAY-985

Product Name: BAY-985
CAS No.: 2409479-29-2
Chemical Name: BAY-985
Synonyms: BAY-985;BAY-985,IKK,BAY985,IκB kinase,melanoma,IKKε,TBK1,inhibit,I kappa B kinase,Inhibitor,BAY 985,antitumor;1-Propanone, 1-[4-[(1R)-1-[2-[[6-[6-(dimethylamino)-4-pyrimidinyl]-1H-benzimidazol-2-yl]amino]-4-pyridinyl]ethyl]-1-piperazinyl]-3,3,3-trifluoro-;(R)-1-(4-(1-(2-((6-(6-(Dimethylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-yl)amino)pyridin-4-yl)ethyl)piperazin-1-yl)-3,3,3-trifluoropropan-1-one
CBNumber: CB55839640
Molecular Formula: C27H30F3N9O
Formula Weight: 553.58
MOL File: 2409479-29-2.mol

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BAY-985 Property

Boiling point:: 753.3±70.0 °C(Predicted)
Density: 1.373±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 50 mg/mL (90.32 mM)
form: A solid
pka: 10.06±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0112070
Product name: BAY-985
Purity: 99.87%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0112070
Product name: BAY-985
Purity: 99.87%
Packaging: 10mg
Price: $880
Updated: 2021/12/16

ChemScene

Product number: CS-0112070
Product name: BAY-985
Purity: 99.87%
Packaging: 50mg
Price: $1950
Updated: 2021/12/16

DC Chemicals

Product number: 012784
Product name: BAY-985
Packaging: 002
Price: $1500
Updated: 2021/12/16

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BAY-985 Chemical Properties,Usage,Production

Biological Activity

BAY-985 is a potent and highly selective TBK1/IKKε inhibitor. It is highly potent against TBK1 (IC50 = 2 nM, low ATP assay; 30 nM, high ATP assay) and IKKε (IC50 = 2 nM) and also in mechanocellular phosphorylation of interferon regulatory factor 3 (pIRF3) assays High potency (IC50 = 74 nM) and anti-proliferative effect on SK-MEL-2 cells (IC50 = 900 nM).

in vitro

BAY-985 inhibits FLT3, RSK4, DRAK1, and ULK1 with IC ₅₀ s of 123, 276, 311, and 7930 nM, respectively.
BAY-985 inhibits the cellular phosphorylation of interferon regulatory factor 3 (IRF3) with an IC ₅₀ of 74 nM.
BAY-985 is active in cellular mechanistic assay and shows anti-proliferative activity in a few cancer cells lines with IC ₅₀ s of 900 and 7260 nM for SK-MEL2 (NRAS and TP53 mutated) and ACHN (CDKN2A mutated) cells, respectively.

Cell Proliferation Assay

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Cell Line:	ACHN and SK-MEL-2 cell lines
Concentration:
Incubation Time:	96 hours
Result:	Inhibited proliferation i n SK-MEL2 and ACHN cells with IC ₅₀ s of 900 and 7260 nM, respectively.

in vivo

BAY-985 (200 mg/kg; po; bid; 111 days) results in weak antitumor efficacy.
BAY-985 shows high clearance (CL _b = 4.0 L/h/kg, ca. 95% hepatic extraction), large volume of distribution at steady state (V _ss =2.9 L/kg) and a short terminal half-life (t _{1 /2} =0.79 h).

Animal Model:	Female NMRI nude mice bearing SK-MEL-2 human melanoma xenograft model
Dosage:	200 mg/kg
Administration:	Applied po; twice daily (bid) continuously 111 days
Result:	Treatment resulted in weak antitumor efficacy with a T/C _{tumor weight} ratio of 0.6. The treatment was well tolerated, with a maximum body weight loss of less than 10%.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> TBK1
(in high ATP assay)

Target	Value
TBK1 (in low ATP assay)	2 nM
IKKε (Cell-free assay)	2 nM
30 nM
pIRF3 (Cell-free assay)	74 nM

BAY-985 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-985 Suppliers

China 30 United States 4 Global 34

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 283
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9452
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3421
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4153
Advantage: 55

Twochem Co.Ltd

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 290
Advantage: 55

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29797
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Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1836
Advantage: 55

Shanghai Changyu Medical Technology Co. Ltd.

Tel: +86-13301875428
Email: sales@changyuhe.com
Country: China
ProdList: 290
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Shijiazhuang Leather Bureau Chemical Technology Co., Ltd.

Tel: 13020863400
Email: liaoy124@163.com
Country: China
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Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10523
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BAY-985

1-Propanone, 1-[4-[(1R)-1-[2-[[6-[6-(dimethylamino)-4-pyrimidinyl]-1H-benzimidazol-2-yl]amino]-4-pyridinyl]ethyl]-1-piperazinyl]-3,3,3-trifluoro-

BAY-985,IKK,BAY985,IκB kinase,melanoma,IKKε,TBK1,inhibit,I kappa B kinase,Inhibitor,BAY 985,antitumor

(R)-1-(4-(1-(2-((6-(6-(Dimethylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-yl)amino)pyridin-4-yl)ethyl)piperazin-1-yl)-3,3,3-trifluoropropan-1-one

2409479-29-2

C27H30F3N9O