ChemicalBook > CAS DataBase List > BAY-1125976.

BAY-1125976.

Product Name
BAY-1125976.
CAS No.
1402608-02-9
Chemical Name
BAY-1125976.
Synonyms
CS-2913;BAY1125976;BAY 1125976;BAY-1125976.;BAY-1125976; BAY 1125976;inhibit,Inhibitor,Protein kinase B,Akt,BAY 1125976,BAY1125976,PKB,BAY-1125976;2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide;Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-
CBNumber
CB73133467
Molecular Formula
C23H21N5O
Formula Weight
383.45
MOL File
1402608-02-9.mol
More
Less

BAY-1125976. Property

storage temp. 
Store at -20°C
solubility 
DMSO:13.0(Max Conc. mg/mL);33.9(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);13.04(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.65(Max Conc. mM)
form 
A crystalline solid
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
28913
Product name
BAY-1125976
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
28913
Product name
BAY-1125976
Packaging
25mg
Price
$533
Updated
2024/03/01
Cayman Chemical
Product number
28913
Product name
BAY-1125976
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
28913
Product name
BAY-1125976
Packaging
10mg
Price
$243
Updated
2024/03/01
AK Scientific
Product number
2002DU
Product name
2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide
Packaging
5mg
Price
$252
Updated
2021/12/16
More
Less

BAY-1125976. Chemical Properties,Usage,Production

Description

BAY-1125976 is an allosteric inhibitor of Akt1 and -2 (IC50s = 5.2 and 18 nM, respectively, in a time-resolved FRET assay). It is selective for Akt1 and -2 over Akt3 (IC50 = 427 nM in the same assay) but does inhibit the activity of the receptor tyrosine kinases FLT1, -3, -4, and Mer by greater than 50% in a panel of 227 kinases at 1 μM. BAY-1125976 inhibits the proliferation of 23 cancer cell lines (IC50s = 0.02-10 μM) and reduces tumor growth in KPL-4, MCF-7, and patient-derived xenograft (PDX) mouse models when administered at a dose of 50 mg/kg per day.

BAY-1125976. Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

BAY-1125976. Suppliers

China 47 United States 5 Global 52
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3063
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4153
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
993
Advantage
55
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.
Tel
027-65388397 18164111589
Fax
027-65388397
Email
3321478047@qq.com
Country
China
ProdList
1992
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8013
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2985
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Fax
21-5161 9052
Email
info@SuperLan-chem.com
Country
China
ProdList
9737
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29797
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58

1402608-02-9, BAY-1125976.Related Search:

BAY1895344 2HCl BAY-2402234 BAY-885 BAY-985 BAY 1316957) BAY-1163877 BAY1895344 HCl BAY-1895344 Benzamide, N-[5-(3,5-dicyano-1,4-dihydro-1,2,6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethyl- BAY 2666605 BAY 2416964

  • 2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide
  • BAY-1125976; BAY 1125976
  • CS-2913
  • BAY 1125976
  • BAY1125976
  • BAY-1125976.
  • Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-
  • inhibit,Inhibitor,Protein kinase B,Akt,BAY 1125976,BAY1125976,PKB,BAY-1125976
  • 1402608-02-9