BAY-2402234

Product Name: BAY-2402234
CAS No.: 2225819-06-5
Chemical Name: BAY-2402234
Synonyms: BAY-2402234;Orludodstat (BAY 2402234);BAY-2402234, 10 mM in DMSO;Orludodstat (BAY 2402234) ，S8847;inhibit,BAY 2402234,Inhibitor,DHODH,DNA/RNA Synthesis,BAY2402234,BAY-2402234,Dihydroorotate Dehydrogenase;N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-3-(hydroxymethyl)-5-oxo-1,2,4-triazol-1-yl]-5-fluoro-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxybenzamide;(S)-N-(2-Chloro-6-fluorophenyl)-4-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-((1,1,1-trifluoropropan-2-yl)oxy)benzamide;Benzamide, N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-4,5-dihydro-3-(hydroxymethyl)-5-oxo-1H-1,2,4-triazol-1-yl]-5-fluoro-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]-
CBNumber: CB84797025
Molecular Formula: C21H18ClF5N4O4
Formula Weight: 520.84
MOL File: 2225819-06-5.mol

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BAY-2402234 Property

Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMF:10.0(Max Conc. mg/mL);19.2(Max Conc. mM)
DMSO:78.33(Max Conc. mg/mL);150.39(Max Conc. mM)
Ethanol:31.5(Max Conc. mg/mL);60.48(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.48(Max Conc. mM)
form: A crystalline solid
pka: 10.57±0.70(Predicted)
color: White to light yellow
InChIKey: KNVJMHHAXCPZHF-JTQLQIEISA-N
SMILES: C(NC1=C(F)C=CC=C1Cl)(=O)C1=CC(F)=C(N2C(=O)N(CC)C(CO)=N2)C=C1O[C@@H](C)C(F)(F)F

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0058850
Product name: BAY-2402234
Purity: 99.95%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0058850
Product name: BAY-2402234
Purity: 99.95%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0058850
Product name: BAY-2402234
Purity: 99.95%
Packaging: 25mg
Price: $1750
Updated: 2021/12/16

ChemScene

Product number: CS-0058850
Product name: BAY-2402234
Purity: 99.95%
Packaging: 50mg
Price: $2750
Updated: 2021/12/16

ChemScene

Product number: CS-0058850
Product name: BAY-2402234
Purity: 99.95%
Packaging: 100mg
Price: $3950
Updated: 2021/12/16

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BAY-2402234 Chemical Properties,Usage,Production

Uses

BAY-2402234 is a selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies.

in vivo

BAY-2402234 exhibits strong in vivo anti-tumor efficacy in monotherapy in several subcutaneous and disseminated AML xenografts as well as AML patient-derived xenograft (PDX) models. Target engagement of the novel DHODH inhibitor BAY-2402234 can be observed by increase of tumoral and plasma dihydroorotate levels after treatment with the inhibitor. Consistent with the in vitro data BAY-2402234 induces AML differentiation in vivo as detected by upregulation of differentiation cell surface markers in xenograft and PDX models after treatment with the inhibitor. Furthermore, differentiation-associated transcriptomic changes are evident following a single administration of BAY-2402234 in vivo^[1].

References

[1] Andreas Janzer, et al. Abstract DDT02-04: BAY 2402234: A novel, selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies. AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL.

BAY-2402234 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-2402234 Suppliers

China 61 United States 5 Global 66

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2225819-06-5, BAY-2402234Related Search:

BAY1895344 2HCl BAY-1125976. BAY-885 BAY-985 BAY 1316957) BAY-1163877 BAY1895344 HCl BAY-1895344 Benzamide, N-[5-(3,5-dicyano-1,4-dihydro-1,2,6-trimethyl-4-pyridinyl)-6-fluoro-7-methyl-1H-indazol-3-yl]-2-ethyl- BAY 2666605 BAY 2416964

BAY-2402234

Benzamide, N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-4,5-dihydro-3-(hydroxymethyl)-5-oxo-1H-1,2,4-triazol-1-yl]-5-fluoro-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]-

N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-3-(hydroxymethyl)-5-oxo-1,2,4-triazol-1-yl]-5-fluoro-2-[(2S)-1,1,1-trifluoropropan-2-yl]oxybenzamide

inhibit,BAY 2402234,Inhibitor,DHODH,DNA/RNA Synthesis,BAY2402234,BAY-2402234,Dihydroorotate Dehydrogenase

(S)-N-(2-Chloro-6-fluorophenyl)-4-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-((1,1,1-trifluoropropan-2-yl)oxy)benzamide

BAY-2402234, 10 mM in DMSO

Orludodstat (BAY 2402234)

Orludodstat (BAY 2402234) ，S8847

2225819-06-5

C21H18ClF5N4O4