ChemicalBook > CAS DataBase List > BAY-885

BAY-885

Use In vitro

Product Name: BAY-885
CAS No.: 2307249-33-6
Chemical Name: BAY-885
Synonyms: BAY-885;BAY-885 USP/EP/BP;BAY885, 10 mM in DMSO;BAY 885,ERK,inhibit,Extracellular signal regulated kinases,Inhibitor,BAY885,BAY-885;[2-amino-4-(trifluoromethoxy)phenyl]-{4-[7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl]piperidin-1-yl}methanone;Methanone, [2-amino-4-(trifluoromethoxy)phenyl][4-[7-(4-methyl-1-piperazinyl)pyrido[3,2-d]pyrimidin-4-yl]-1-piperidinyl]-
CBNumber: CB64667614
Molecular Formula: C25H28F3N7O2
Formula Weight: 515.53
MOL File: 2307249-33-6.mol

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BAY-885 Property

Boiling point:: 685.0±55.0 °C(Predicted)
Density: 1.362±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO:23.33(Max Conc. mg/mL);45.25(Max Conc. mM)
Ethanol:8.0(Max Conc. mg/mL);15.52(Max Conc. mM)
form: A solid
pka: 7.06±0.42(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb611265
Product name: BAY-885
Purity: >98%
Packaging: 10mg
Price: $1208.7
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611265
Product name: BAY-885
Purity: >98%
Packaging: 25mg
Price: $1802
Updated: 2021/12/16

ChemScene

Product number: CS-0043294
Product name: BAY885
Purity: 99.15%
Packaging: 50mg
Price: $2600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611265
Product name: BAY-885
Purity: >98%
Packaging: 50mg
Price: $2691.1
Updated: 2021/12/16

ChemScene

Product number: CS-0043294
Product name: BAY885
Purity: 99.15%
Packaging: 100mg
Price: $3600
Updated: 2021/12/16

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BAY-885 Chemical Properties,Usage,Production

Use

BAY-885 is a highly potent and selective ERK5 inhibitor.

In vitro

BAY-885 shows potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM) and has no effects on a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM), thereby ruling out potential effects as a general inhibitor of transcription or translation.

Uses

BAY885 is a highly potent and selective ERK5 inhibitor with an IC50 of 35 nM. BAY885 shows weak inhibition on others kinases[1].

Biological Activity

BAY-885 is an ATP site-targeting, potent and selective ERK5 (BMK1, MAPK7) inhibitor (IC50 = 35 nM with 250 μM ATP; % inhibition at 1 μM = 62/r at Fer, 58/human EphB3, 43/human EphA5, =20/355 kinases) with no BRD4 affinity (20 μM), nor inhibitory potency toward hERG (10 μM) and CYP enzymes (20 μM; CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A4). BAY-885 potently inhibits 100 ng/mL EGF-induced, ERK5-dependent MEF2 activity (IC50 = 120 nM; SN12C-MEF2-luc reporter assay).

IC 50

ERK5: 35 nM (IC₅₀)

References

[1] Nguyen D, et al. Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5. J Med Chem. 2019 Jan 24;62(2):928-940. DOI:10.1021/acs.jmedchem.8b01606

BAY-885 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-885 Suppliers

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2307249-33-6, BAY-885Related Search:

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BAY-885

[2-amino-4-(trifluoromethoxy)phenyl]-{4-[7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl]piperidin-1-yl}methanone

Methanone, [2-amino-4-(trifluoromethoxy)phenyl][4-[7-(4-methyl-1-piperazinyl)pyrido[3,2-d]pyrimidin-4-yl]-1-piperidinyl]-

BAY-885 USP/EP/BP

BAY 885,ERK,inhibit,Extracellular signal regulated kinases,Inhibitor,BAY885,BAY-885

BAY885, 10 mM in DMSO

2307249-33-6

C25H28F3N7O2