BAY 2416964
BAY 2416964 Basic information
- Product Name:
- BAY 2416964
- Synonyms:
-
- AHR antagonist 3
- (S)-6-(4-chlorophenyl)-N-(1-hydroxypropan-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide
- 4-Pyridazinecarboxamide, 6-(4-chlorophenyl)-2,3-dihydro-N-[(1S)-2-hydroxy-1-methylethyl]-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-
- 6-(4-chlorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-2-(1-methylpyrazol-4-yl)-3-oxopyridazine-4-carboxamide
- BAY 2416964 USP/EP/BP
- BAY241696
- BAY 2416964, 10 mM in DMSO
- CAS:
- 2242464-44-2
- MF:
- C18H18ClN5O3
- MW:
- 387.82
- Mol File:
- 2242464-44-2.mol
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BAY 2416964 Chemical Properties
- Density
- 1.42±0.1 g/cm3(Predicted)
- solubility
- DMSO:64.0(Max Conc. mg/mL);165.02(Max Conc. mM)
- pka
- 11.81±0.20(Predicted)
- form
- Solid
- color
- Light yellow to green yellow
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BAY 2416964 Usage And Synthesis
Use
BAY 2416964 (compound 192) is a potent and orally active antagonist of aryl hydrocarbon receptor (AhR) with IC50 of 341 nM. BAY 2416964 has the potential in the treatment of solid tumors.
In vitro
BAY 2416964 (Example 192) induces AHR-regulated gene CYP1A1 expression with IC50 of 4.30 nM in a human monocytic U937 cells.
In vivo
BAY 2416964 (Example 192) is dissolved in Ethanol/Solutol/Water (10/40/50) and given at 30 mg/kg, QD, p.o.. The efficacy is calculated based on tumor volume. BAY 2416964 (Example 192) is shown to have the potential for solid tumour treatment.
BAY 2416964Supplier
ShangHai Caerulum Pharma Discovery Co., Ltd. Gold
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
Qingdao Marine Biomedical Research Institute Co., Ltd. Gold
- Tel
- 0532-85906825 18366218597
- wizard.s.bzh@163.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
ShangHai Biochempartner Co.,Ltd
- Tel
- 17754423994 17754423994
- 2853530910@QQ.com
Shanghai Chaolan Chemical Technology Center
- Tel
- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com