Benzamide, N-(4-iodophenyl)-4-(4-morpholinylmethyl)- Chemical Properties

Boiling point:

435.4±45.0 °C(Predicted)

Density 

1.576±0.06 g/cm3(Predicted)

pka

12.90±0.70(Predicted)

form 

Solid

color 

White to off-white

Benzamide, N-(4-iodophenyl)-4-(4-morpholinylmethyl)- Usage And Synthesis

Uses

HIF-1 inhibitor-4 is a HIF-1 inhibitor (IC50: 560 nM). HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level[1].

References

[1] Nagao S, et al. Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5513-29. DOI:10.1016/j.bmc.2014.07.020

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