Ethanone, 1-(4-bromophenyl)-2-[[5-(4-pyridinyl)-1,3,4-oxadiazol-2-yl]thio]- Chemical Properties

Boiling point:

570.1±60.0 °C(Predicted)

Density 

1.65±0.1 g/cm3(Predicted)

pka

0.93±0.10(Predicted)

form 

Solid

color 

Light yellow to khaki

Ethanone, 1-(4-bromophenyl)-2-[[5-(4-pyridinyl)-1,3,4-oxadiazol-2-yl]thio]- Usage And Synthesis

Uses

FAK-IN-10 is an inhibitor of FAK with an IC50 of 76.3 μM. FAK-IN-10 exhibits antitumor activity against MCF-7 and A431 cell lines with IC50s of 4.23 and 0.78 μM,respectively[1].

References

[1] Zhang LR, et al. Synthesis, biological evaluation and molecular docking studies of novel 2-(1,3,4-oxadiazol-2-ylthio)-1-phenylethanone derivatives. Bioorg Med Chem. 2012 Jun 1;20(11):3615-21. DOI:10.1016/j.bmc.2012.03.061

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