3-chloro-4-morpholin-4-yl-1-phenylpyrrole-2,5-dione Chemical Properties

Melting point:

160-161 °C

Boiling point:

402.3±45.0 °C(Predicted)

Density 

1.45±0.1 g/cm3(Predicted)

pka

-3.33±0.60(Predicted)

3-chloro-4-morpholin-4-yl-1-phenylpyrrole-2,5-dione Usage And Synthesis

Uses

RAD51-IN-9 (Compound 3a) is a RAD51 inhibitor that can inhibit the binding of RAD51 to ssDNA with an IC50 of 17.85 μM. RAD51-IN-9 has a LD50 against HEK293 cells of 40.21 μM. RAD51-IN-9 can sensitize cells to Mitomycin C (HY-13316)[1].

References

[1] Budke B, et al. An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity. J Med Chem. 2013 Jan 10;56(1):254-63. DOI:10.1021/jm301565b

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