Cyclosporin C
Cyclosporin C Basic information
- Product Name:
- Cyclosporin C
- Synonyms:
-
- CYCLOSPORIN C
- Cyclosporine C/Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-threonyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]
- 30-(1-hydroxyethyl)-33-(1-hydroxy-2-methylhex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriaconta
- CS-2545
- CS-2546
- cyclo-[MeBmt-Thr-Sar-MeLeu-Val-MeLeu-Ala-D-Ala-MeLeu-MeLeu-MeVal]
- Cyclosporine EP Impurity C
- Thr2-cyclosporine
- CAS:
- 59787-61-0
- MF:
- C62H111N11O13
- MW:
- 1218.61
- Product Categories:
-
- Intermediates & Fine Chemicals
- Peptides
- ACTIVE PHARMACEUTICAL INGREDIENTS
- Pharmaceuticals
- Mol File:
- 59787-61-0.mol
Cyclosporin C Chemical Properties
- Melting point:
- 144-1460C
- alpha
- D20 -255° (c = 0.5 in chloroform); D20 -182° (c = 0.5 in methanol)
- Boiling point:
- 1316.0±65.0 °C(Predicted)
- Density
- 1.033±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO: ≥10mg/mL
- pka
- 13.06±0.70(Predicted)
- form
- Colorless to off-white crystalline solid.
- color
- White to Off-White
- InChIKey
- JTOKYIBTLUQVQV-PCACHRFWSA-N
- CAS DataBase Reference
- 59787-61-0
Cyclosporin C Usage And Synthesis
Description
Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties. It is active against isolates of B. cinerea, A. niger, and Alternaria, Mucor, and Penicillium species (MICs = 0.1-5 μg/ml). Cyclosporin C (15 μg/ml) inhibits vaccinia virus replication in infected BSC40 cells by 98.82%. It inhibits lymphocyte proliferation induced by the mitogens concanavalin A (ConA; ), phytohemagglutinin L (PHA), and pokeweed mitogen (PWM), as well as proliferation induced by alloantigen in mixed lymphocyte culture when used at a concentration of 100 ng/ml. Cyclosporin C (100 ng/ml) inhibits the local graft versus host (GVH) reaction in mice receiving splenocyte grafts.
Chemical Properties
White Solid
Uses
A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
Uses
Cyclosporin C is a minor analogue of the cyclosporin complex produced by a number of fungal species, including Trichoderma, Tolypocladium, Fusarium, Nectria and Acremonium. Cyclosporin C possesses immunosuppressant activity but has been much less extensively investigated than the major analogue, cyclosporin A.
storage
+4°C
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Cyclosporin C(59787-61-0)Related Product Information
- Methyl acrylate
- (R)-(-)-2-Amino-3-methyl-1-butanol
- Dimethyl sulfone
- Bensulfuron methyl
- VALINOMYCIN
- CYCLOSPORIN D
- CYCLOSPORIN H
- Cyclosporin A
- Phenylmethylsulfonyl fluoride
- Thiophanate-methyl
- Hexamethylphosphoramide
- Kresoxim-methyl
- STAUROSPORINE
- Methylparaben
- METHYL THIOPHENE-2-CARBOXYLATE
- Methyl
- Methyl bromide
- Parathion-methyl