BOC-GLYCINE TERT-BUTYL ESTER Chemical Properties

Melting point:

66-68 °C(lit.)

Boiling point:

306.0±25.0 °C(Predicted)

Density 

1.023

storage temp. 

2-8°C

solubility 

very soluble in Methanol

form 

powder to crystal

pka

11.06±0.46(Predicted)

color 

White to Almost white

Water Solubility 

1.05g/L at 20℃

BRN 

5002580

InChIKey

ZDKFMHKWZATBMR-UHFFFAOYSA-N

LogP

2.21 at 25℃

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-51

Safety Statements 

20/21-29/56

WGK Germany 

3

HS Code 

29241990

MSDS

• Language:English Provider:SigmaAldrich

BOC-GLYCINE TERT-BUTYL ESTER Usage And Synthesis

Chemical Properties

Whtie powder

Uses

peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

Example 1 (Example of reaction formula (1)) [13]: tert-butyl glycinate hydrochloride (10.0 g, 59.7 mmol) was suspended in toluene (46.2 ml), heated to 60 °C and then triethylamine (6.51 g, 64.3 mmol) was added, and the reaction was stirred for 0.5 hours. Subsequently, a solution of di-tert-butyl dicarbonate (10.0 g, 45.9 mmol) in toluene (11.6 ml) was added slowly and dropwise to the reaction mixture and the reaction was continued for 6 hours. After completion of the reaction, it was quenched by addition of water (30 ml) and the organic layer was separated. The organic layer was distilled by azeotropic distillation with n-hexane to remove the solvent to afford tert-butyl N-Boc-glycinate (10.6 g, 45.9 mmol, 100% yield). The structure of the product was confirmed by 1H-NMR analysis.

References

[1] Patent: CN103068795, 2016, B. Location in patent: Paragraph 0119; 0120; 0121; 0122; 0123; 0124
[2] Synthesis, 1987, # 3, p. 223 - 225
[3] The Journal of organic chemistry, 2002, vol. 67, # 24, p. 8291 - 8298

BOC-GLYCINE TERT-BUTYL ESTER(111652-20-1)Related Product Information

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