GUVACINE HYDROCHLORIDE Chemical Properties

Melting point:

295°C (rough estimate)

Boiling point:

235.91°C (rough estimate)

Density 

1.1931 (rough estimate)

refractive index 

1.4645 (estimate)

storage temp. 

Store at RT

solubility 

H₂O: soluble

form 

solid

pka

3.61±0.20(Predicted)

color 

white

CAS DataBase Reference

498-96-4

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

MSDS

• Language:English Provider:SigmaAldrich

GUVACINE HYDROCHLORIDE Usage And Synthesis

Uses

Guvacine Hydrochloride is a GABA uptake inhibitor (hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1) (1,2,3). Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain (4). Guvacine Hydrochloride may be useful for treating neuropsychiatric disorders.

Definition

ChEBI: A alpha,beta-unsaturated monocarboxylic acid that is nicotinic acid which has been hydrogenated at the 1-2 and 5-6 positions of the pyridine ring.

Biological Activity

Specific GABA uptake inhibitor. IC 50 values are 14, 58, 119 and 1870 mM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively.

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