Basic information Safety Supplier Related

(GLY14)-HUMANIN (HUMAN)

Basic information Safety Supplier Related

(GLY14)-HUMANIN (HUMAN) Basic information

Product Name:
(GLY14)-HUMANIN (HUMAN)
Synonyms:
  • MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA
  • MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA TRIFLUOROACETATE
  • MAPRGFSCLLLLTGEIDLPVKRRA
  • H-MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA-OH
  • MAPGSGCLLLLTGEIDLPVKRRA
  • [GLY14]-HN
  • [GLY14]-HUMANIN
  • [GLY14] HUMANIN G (HNG), HUMAN
CAS:
330936-70-4
MF:
C118H202N34O31S2
MW:
2657.21
Product Categories:
  • peptide
  • Alzheimers and Neurodegenerative Disease Research
  • Neurobiology
  • Neurodegenerative Disease Peptides
  • Other Alzheimer Peptides
  • OtherNeuropeptides
Mol File:
330936-70-4.mol
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(GLY14)-HUMANIN (HUMAN) Chemical Properties

storage temp. 
−70°C
form 
solid
color 
White to off-white
biological source
human
Water Solubility 
water: 1.00-1.04mg/mL, clear, colorless
InChIKey
WUYRHUFIUFJVQU-LIRFXKSTNA-N
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Safety Information

WGK Germany 
3

MSDS

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(GLY14)-HUMANIN (HUMAN) Usage And Synthesis

Uses

[Gly14]-Humanin G human has been used:

  • along with bortezomib in pharmacological inhibition studies to tre at mice to limit the toxic effects of bortezomib
  • to study its effect on high glucose (HG)-induced apoptosis of endothelial cells (ECs)
  • to study its neuroprotective effects in an in vitro oxygen-glucose deprivation/reoxygenation (OGD/R) model using SH-SY5Y neuroblastoma cells
', '[Gly1?]-Humanin G human has been used to limit the toxicity during the bortezomib treatment in neonatal brachial plexus injury (NBPI) mice model. It has also been used in the cell culture of the human-derived neuroblastoma cell line.

Biological Activity

Endogenous rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimerμs disease genes and Aβ', '[Gly14]-humanin (HNG) stimulates cell growth, proliferation, and cell cycle progression. It enhances proteins such as kinases, transporters, transmembrane receptors, and transcription and translational regulators. HNG exhibits intense in vitro neuroprotective effects compared to natural HN. Studies show th at it is an effective cytoprotectant both in vitro and in vivo. HNG is found to prevent high glucose (HG)-induced apoptosis of endothelial cells (ECs). It is proven to inhibit AngII-induced phenotypic switch in vascular smooth muscle cells (VSMCs).

in vivo

(Gly14)-Humanin (human) (0.1 μg/5 μL; i.c.v.; once) decreases cells with plasmalemma permeability in the injured cortex and hippocampus, reduces brain lesion volume, improves motor performance and ameliorates performance in the Morris water maze test[2].

Animal Model:Adult male CD-1 mice (25-30 g; 10-12-week-old) bearing traumatic brain injury (TBI)[2]
Dosage:0.1 μg/5 μL
Administration:Intracerebroventricularly (i.c.v.); once
Result:Decreased cells with plasmalemma permeability in the injured cortex and hippocampus, reduced brain lesion volume, improved motor performance.

(GLY14)-HUMANIN (HUMAN)Supplier

Alabiochem Tech.Co., Ltd.
Tel
512-58900862 400-0707518
Email
sales@alabiochem.com
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Email
ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Email
info@cellmano.com
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(GLY14)-HUMANIN (HUMAN)(330936-70-4)Related Product Information