2-AMINO-5-METHYLBENZYL ALCOHOL Chemical Properties

Melting point:

123-126 °C(lit.)

Boiling point:

145-150 °C(Press: 13 Torr)

Density 

1.126±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

14.48±0.10(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

2-AMINO-5-METHYLBENZYL ALCOHOL Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-amino-5-methylbenzenemethanol from 2-amino-5-methylbenzoic acid: lithium aluminum hydride (20.4 mmol) was suspended in tetrahydrofuran (THF, 10 mL) at room temperature, followed by slow dropwise addition of a solution of 2-amino-5-methylbenzoic acid (8.5 mmol) dissolved in THF (24 mL) over a period of 20 min. The reaction mixture was stirred continuously for 3.5 h at room temperature. Upon completion of the reaction, the reaction was carefully quenched with deionized water (10 mL) at 0 °C. The resulting suspension was filtered through a diatomaceous earth pad and the filter cake was washed well with ethyl acetate (EtOAc, 100 mL). The combined organic phases were washed with saturated saline (30 mL), dried over anhydrous magnesium sulfate (MgSO?), and finally concentrated under reduced pressure to give the target product 2-amino-5-methylbenzyl alcohol.

References

[1] ACS Catalysis, 2013, vol. 3, # 4, p. 622 - 624
[2] Chemical Communications, 2017, vol. 53, # 1, p. 216 - 219
[3] Organic Letters, 2017, vol. 19, # 12, p. 3219 - 3222
[4] Tetrahedron Letters, 2017, vol. 58, # 40, p. 3795 - 3799
[5] Patent: US5190971, 1993, A

2-AMINO-5-METHYLBENZYL ALCOHOL(34897-84-2)Related Product Information

• 2-Amino-5-methylbenzoic acid
• MBAA
• 4,4'-DIAMINOBIPHENYL-3,3'-DICARBOXYLIC ACID
• ETHYL 2-AMINO-5-METHYLBENZOATE
• 2-AMINO-3-BROMO-5-METHYLBENZOIC ACID
• 2-AMINO-5-METHYLBENZYL ALCOHOL
• 5-Methyl-2-nitrobenzoic acid
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