Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Chemical Properties

Melting point:

288 °C

Boiling point:

612.3±54.0 °C(Predicted)

Density 

1.578±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Soluble in DMSO (up to 15 mg/ml with warming) or in DMF (up to 15 mg/ml)

form 

solid

color 

Orange

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.

Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Usage And Synthesis

Description

Seriniquinone (22200-69-7) is a new natural product isolated from a marine bacterium of the genus Serinicoccus. Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma. Upon cellular treatment, seriniquinone was found to localize in the endoplasmic reticulum. Within 3 hours cells underwent autophagy followed by death via a caspase-9 apoptotic pathway. The target of seriniquinone was identified as the small protein, dermcidin, as determined using an immunoaffinity approach.1

Uses

Seriniquinone is a marine natural product, that displays potent cytotoxicity and selectivity against melanoma cancer cells.

References

1) Trzoss?et al. (2014),?Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin; Proc. Natl. Acad. Sci. USA,?111?14687

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