YM155 Chemical Properties

Melting point:

>180°C (dec.)

storage temp. 

-20°

solubility 

Soluble in DMSO (up to 25 mg/ml).

form 

solid

color 

Tan to yellow

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

InChI

InChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1

InChIKey

QBIYUDDJPRGKNJ-UHFFFAOYSA-M

SMILES

c12[n+](Cc3nccnc3)c(C)[n](CCOC)c1C(=O)c1ccccc1C2=O.[Br-]

Safety Information

HS Code 

29339900

YM155 Usage And Synthesis

Description

YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1?Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2?Induces DNA damage.3?YM-155 induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4

Uses

YM155 is a potent IAP (inhibitor of apoptosis proteins) inhibitor for survivin with IC50 of 0.54 nM.

Uses

YM155 is a novel small-molecule survivin suppressant that suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC. cell lines. Potent Survivin Inhibitor.

Definition

ChEBI: Sepantronium bromide is an organic bromide salt consisting of sepantronium cations and bromide anions. It has been found to selectively inhibit survivin (BIRC5) gene promoter activity and to down-regulate survivin in vitro, so leading to induction of apoptosis. It has a role as an antineoplastic agent, a survivin suppressant and an apoptosis inducer. It contains a sepantronium.

target

Survivin

storage

Store at -20°C

References

[1] TAKAHITO NAKAHARA. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts.[J]. Cancer research, 2007, 67 17: 8014-8021. DOI:10.1158/0008-5472.can-07-1343
[2] K. OKAMOTO. Overcoming Erlotinib Resistance in EGFR Mutation-Positive Non-Small-Cell Lung Cancer Cells by Targeting Survivin[J]. Annals of Oncology, 2012, 23 1. DOI:10.1016/s0923-7534(20)32199-2
[3] TREVOR G GLAROS. The “survivin suppressants” NSC 80467 and YM155 induce a DNA damage response.[J]. Cancer Chemotherapy and Pharmacology, 2012: 207-212. DOI:10.1007/s00280-012-1868-0
[4] YU-FAN WANG. Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma[J]. Apoptosis, 2013, 19 4: 748-758. DOI:10.1007/s10495-013-0960-1

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