1-Boc-3-(cyanomethylene)azetidine Chemical Properties

Boiling point:

309.7±35.0 °C(Predicted)

Density 

1.215

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder to crystal

pka

-1.88±0.20(Predicted)

color 

White to Orange to Green

Safety Information

RIDADR 

UN 3439 6.1/PG III

HazardClass 

6.1

PackingGroup 

III

HS Code 

2933998090

1-Boc-3-(cyanomethylene)azetidine Usage And Synthesis

Uses

1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine is used in the synthesis of baricitinib via Horner-Emmons reaction of tert-butyl-oxoazetidine-carboxylate followed by sulfonamidation, nucleophilic addition. and subsequent Suzuki-coupling reaction.

Uses

1-(tert-Butoxycarbonyl)-3-(cyanomethylene)azetidine is used in the synthesis of baricitinib via Horner-Emmons reaction of tert-butyl-oxoazetidine-carboxylate followed by sulfonamidation, nucleophilic addition. and subsequent Suzuki-coupling reaction.

1-Boc-3-(cyanomethylene)azetidine(1153949-11-1)Related Product Information

• 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester
• 1-N-Boc-3-hydroxyazetidine
• (R)-1-Boc-2-cyanopyrrolidine
• tert-butyl 4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoyl)piperazine-1-carboxylate
• 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• 3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• N-Boc-pyrroline
• tert-butyl 3-broMo-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate
• tert-Butyl 4-broMo-1H-pyrrolo[2,3-c]pyridine-1-carboxylate
• Baricitinib
• tert-butyl 3-oxidanyl-3-pyridin-2-yl-azetidine-1-carboxylate
• tert-butyl 4-((4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)Methyl)piperazine-1-carboxylate
• 1-Boc-Azetidine-3-yl-methanol
• tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate
• tert-butyl 2,2,4,8-tetraMethyl-1,2,3,4-tetrahydroquinolin-7-ylcarbaMate
• tert-butyl 3-(4-(7-carbamoyl-2H-indazol-2-yl)phenyl)piperidine-1-carboxylate
• tert-butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)aMino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate
• tert-butyl 2-(3-hydroxy-1-(2,2,2-trifluoroacetyl)azetidin-3-yl)piperidine-1-carboxylate