Pardoprunox Chemical Properties

Density 

1.258±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

9.15±0.70(Predicted)

Pardoprunox Usage And Synthesis

Uses

Pardoprunox (SLV-308) is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively[1].

IC 50

5-HT_1A Receptor: 6.3 (pEC₅₀); D₂ Receptor: 8 (pEC₅₀); D₃ Receptor: 9.2 (pEC₅₀)

References

[1] Glennon JC, et al. In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist. Synapse. 2006 Dec 15;60(8):599-608. DOI:10.1002/syn.20330
[2] Bronzova J, et al. Double-blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's disease. Mov Disord. 2010 Apr 30;25(6):738-46. DOI:10.1002/mds.22948
[3] Bétry C, et al. In vivo effects of pardoprunox (SLV308), a partial D?/D? receptor and 5-HT1A receptor agonist, on rat dopamine and serotonin neuronal activity. Synapse. 2011 Oct;65(10):1042-51. DOI:10.1002/syn.20936

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