Hyptadienic acid Chemical Properties

Melting point:

208-210 °C

Boiling point:

590.6±50.0 °C(Predicted)

Density 

1.16±0.1 g/cm3(Predicted)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

pka

4.48±0.70(Predicted)

Hyptadienic acid Usage And Synthesis

Description

Hyptadienic acid exhibits moderate cytotoxicity against HepG2 cells. Hyptadienic acid shows a marked anti-inflammatory effect, it also exhibits strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter.

Uses

Hyptadienic acid is a triterpene acid that can be isolated from the leaves of Perilla frutescens. Hyptadienic acid inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice with an ID50 value of 0.13 mg/ear. Hyptadienic acid can be used for the research of inflammation[1].

target

Immunology & Inflammation related

References

[1] Banno N, et al. Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects. Biosci Biotechnol Biochem. 2004 Jan;68(1):85-90. DOI:10.1271/bbb.68.85

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