Basic information Safety Supplier Related

Amiodarone-D4 HCl

Basic information Safety Supplier Related

Amiodarone-D4 HCl Basic information

Product Name:
Amiodarone-D4 HCl
Synonyms:
  • Amiodarone-D4 hydrochloride solution
  • (2-butyl-1-benzofuran-3-yl)-[3,5-diiodo-4-[1,1,2,2-tetradeuterio-2-(diethylamino)ethoxy]phenyl]methanone:hydrochloride
  • AMIODARONE HCL (D4, 98%) 100 UG/ML IN METHANOL (AS FREE BASE)
  • [2H4]-Amiodarone Hydrochloride
  • Amiodarone hydrochloride salt
  • Amiodarone D4 HydrochlorideQ: What is Amiodarone D4 Hydrochloride Q: What is the CAS Number of Amiodarone D4 Hydrochloride Q: What is the storage condition of Amiodarone D4 Hydrochloride Q: What are the applications of Amiodarone D4 Hydrochloride
  • Prosulfocarb Impurity 3-d10
  • Amiodarone-d4 hydrochloride (ethoxy-d4) in methanol
CAS:
1216715-80-8
MF:
C25H30ClI2NO3
MW:
681.78
EINECS:
806-400-9
Mol File:
1216715-80-8.mol
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Amiodarone-D4 HCl Chemical Properties

Flash point:
9℃
storage temp. 
-20°C
solubility 
DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml
form 
A solid
color 
White to off-white
Stability:
Very Hygroscopic
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Safety Information

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
7-16-36/37-45
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
1
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Amiodarone-D4 HCl Usage And Synthesis

Description

Amiodarone-d4 is intended for use as an internal standard for the quantification of amiodarone by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 μM. In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6 and 0.65 μM, respectively). It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.

Uses

A Labelled non-selective ion channel blocker. Antiarrhythmic (class III).

General Description

A Certified Spiking Solution?and stable-labeled internal standard for use in therapeutic drug monitoring analyses by LC/MS. Amiodarone, an antiarrhythmic agent marketed as Pacerone?, Cordarone?, Aratac, Atlansil, is monitored by clinical labs to ensure patients remain within the drug′s therapeutic range.

Amiodarone-D4 HClSupplier

Sigma-Aldrich
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021-61415566 800-8193336
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Artis Biotech Co. Ltd.
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Shanghai EFE Biological Technology Co., Ltd.
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Shenzhen SUNGENING Bio-Medical Co., Ltd.
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0755-28967200 13631290199
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Nanjing Haolv Biotechnology Co.,Ltd
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025-84622273 17361806303
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