D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT Chemical Properties

Melting point:

>291°C (dec.)

storage temp. 

-20°C

solubility 

PBS (pH 7.2): 10 mg/ml

form 

A crystalline solid

color 

White to light yellow

optical activity

[α]/D 8.5±1.5°, c = 1 in NaOH

Water Solubility 

Soluble to 100 mM in water

BRN 

5318041

Stability:

Hygroscopic

InChIKey

DZHFTEDSQFPDPP-HWYNEVGZSA-L

Safety Information

WGK Germany 

3

HS Code 

29181990

MSDS

• Language:English Provider:SigmaAldrich

D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT Usage And Synthesis

Description

D-α-Hydroxyglutaric Acid (D-2-HG) is an α-hydroxy acid that is over-produced in the human neurometabolic disease D-2-hydroxyglutaric aciduria (D-2-HGA). It is normally synthesized from 2-ketoglutarate (2-KG) by hydroxyacid-oxoacid transhydrogenase (HOT), although defects in HOT are not known to be associated with D-2-HGA. Instead, type I D-2-HGA involves mutations in D-2-hydroxyglutarate dehydrogenase, which converts D-2-HG back to 2-KG. Type II D-2-HGA results from gain-of-function mutations in isocitrate dehydrogenase 2, causing it to supplement HOT in converting 2-KG to D-2-HG. In bacteria, this α-hydroxy acid may be synthesized from oxalate and propionyl-coenzyme A by an α-hydroxyglutaric acid synthetase.

Chemical Properties

Pale Orange Solid

Uses

A potential inhibitor of glutamate carboxypeptidase.

Biochem/physiol Actions

Biomarker for inborn errors of metabolism and cancer

storage

Store at -20°C

D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT(103404-90-6)Related Product Information

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