D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT
- Product Name
- D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT
- CAS No.
- 103404-90-6
- Chemical Name
- D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT
- Synonyms
- d-α-hydroxyglutaric acid disodium salt;sodiuM 2-hydroxypentanedioate;(r)-2-hydroxypentanedioic acid;Disodium (R)-2-hydroxyglutarate;(2R)-2-Hydroxypentanedioic acid;D-A-HYDROXYGLUTARIC ACID DISODIUM;SodiuM (R)-2-hydroxypentanedioate;D-α-Hydroxyglutaric acid disodium;isodium,(2R)-2-hydroxypentanedioate;D-α-Hydroxyglutaricaciddisodiumsalt
- CBNumber
- CB2266017
- Molecular Formula
- C5H9NaO5
- Formula Weight
- 172.11
- MOL File
- 103404-90-6.mol
D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT Property
- Melting point:
- >291°C (dec.)
- storage temp.
- -20°C
- solubility
- PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- color
- White to light yellow
- optical activity
- [α]/D 8.5±1.5°, c = 1 in NaOH
- Water Solubility
- Soluble to 100 mM in water
- BRN
- 5318041
- Stability:
- Hygroscopic
- InChI
- InChI=1/C5H8O5.Na.H/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/t3-;;/s3
- InChIKey
- DZHFTEDSQFPDPP-HWYNEVGZSA-L
- SMILES
- [C@H](O)(C(=O)O)CCC(=O)O.[NaH] |&1:0,r|
Safety
- WGK Germany
- 3
- HS Code
- 29181990
N-Bromosuccinimide Price
- Product number
- 16859
- Product name
- D-α-Hydroxyglutaric acid disodium salt
- Purity
- ≥98.0% (GC)
- Packaging
- 10mg
- Price
- $83.4
- Updated
- 2025/07/31
- Product number
- 16859
- Product name
- D-α-Hydroxyglutaric acid disodium salt
- Purity
- ≥98.0% (GC)
- Packaging
- 50mg
- Price
- $307.44
- Updated
- 2025/07/31
- Product number
- 11605
- Product name
- D-α-Hydroxyglutaric Acid (sodium salt)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 11605
- Product name
- D-α-Hydroxyglutaric Acid (sodium salt)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- H8378
- Product name
- D-α-Hydroxyglutaric acid disodium salt
- Purity
- ≥95% (GC)
- Packaging
- 100mg
- Price
- $495.41
- Updated
- 2025/07/31
D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT Chemical Properties,Usage,Production
Description
D-α-Hydroxyglutaric Acid (D-2-HG) is an α-hydroxy acid that is over-produced in the human neurometabolic disease D-2-hydroxyglutaric aciduria (D-2-HGA). It is normally synthesized from 2-ketoglutarate (2-KG) by hydroxyacid-oxoacid transhydrogenase (HOT), although defects in HOT are not known to be associated with D-2-HGA. Instead, type I D-2-HGA involves mutations in D-2-hydroxyglutarate dehydrogenase, which converts D-2-HG back to 2-KG. Type II D-2-HGA results from gain-of-function mutations in isocitrate dehydrogenase 2, causing it to supplement HOT in converting 2-KG to D-2-HG. In bacteria, this α-hydroxy acid may be synthesized from oxalate and propionyl-coenzyme A by an α-hydroxyglutaric acid synthetase.
Chemical Properties
Pale Orange Solid
Uses
A potential inhibitor of glutamate carboxypeptidase.
Biochem/physiol Actions
Biomarker for inborn errors of metabolism and cancer
storage
Store at -20°C
References
[1] XUDONG FU. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.[J]. Cell metabolism, 2015, 22 3: 508-515. DOI: 10.1016/j.cmet.2015.06.009
[2] ALEXANDRA LATINI. D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats[J]. European Journal of Neuroscience, 2003, 17 10: 2017-2022. DOI: 10.1046/j.1460-9568.2003.02639.x
[3] MARTIJN KRANENDIJK. IDH2 Mutations in Patients with d-2-Hydroxyglutaric Aciduria[J]. Science, 2010, 330 6002. DOI: 10.1126/science.1192632
[4] EDUARD A STRUYS. Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria.[J]. American journal of human genetics, 2005, 76 2: 358-360. DOI: 10.1086/427890
[5] HUI YANG. IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives.[J]. Clinical Cancer Research, 2012, 18 20: 5562-5571. DOI: 10.1158/1078-0432.ccr-12-1773
[6] WEI XU. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.[J]. Cancer Cell, 2011, 19 1: 17-30. DOI: 10.1016/j.ccr.2010.12.014
[7] RASHEDUZZAMAN CHOWDHURY. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.[J]. EMBO Reports, 2011, 12 5: 463-469. DOI: 10.1038/embor.2011.43
D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT manufacturers
- Product
- D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT 103404-90-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 500kg/month
- Release date
- 2019-08-01