ChemicalBook > Product Catalog > Biochemical Engineering > Biochemical Reagents > Agonist Inhibitors > AZ 876
AZ 876
AZ 876 Basic information
- Product Name:
- AZ 876
- Synonyms:
-
- AZ 876
- 2-(1,1-Dimethylethyl)-5-phenyl-4-[[4-(1-piperidinyl)phenyl]amino]-3(2H)-isothiazolone 1,1-dioxide
- AZ876;AZ-876;AZ 876
- 2-tert-butyl-1,1-dioxo-5-phenyl-4-(4-piperidin-1-ylanilino)-1,2-thiazol-3-one
- AZ 12260493
- AZ-12260493.
- AZ-876, AZ12260493
- AZ876; AZ 876; AZ-876, AZ12260493; AZ 12260493; AZ-12260493.
- CAS:
- 898800-26-5
- MF:
- C24H29N3O3S
- MW:
- 439.57
- Product Categories:
-
- APIS
- API
- Mol File:
- 898800-26-5.mol
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AZ 876 Chemical Properties
- Boiling point:
- 605.3±65.0 °C(Predicted)
- Density
- 1.293±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- dmso:94.0(Max Conc. mg/mL);213.84(Max Conc. mM)
- form
- A solid
- pka
- 5.80±0.20(Predicted)
- color
- Yellow to orange
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AZ 876 Usage And Synthesis
Uses
AZ876 is a potent and high-affinity LXR agonist. AZ876 displays 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRα and hLXRβ respectively[1][2].
References
[1] Cannon MV et al. The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects. Eur J Heart Fail. 2015 Mar;17(3):273-82. DOI:10.1002/ejhf.243
[2] van der Hoorn J et al. Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels. Br J Pharmacol. 2011 Apr;162(7):1553-63. DOI:10.1111/j.1476-5381.2010.01168.x
AZ 876Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
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- 17702719238 18971495150;
- sales@sun-shinechem.com
BOC Sciences
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- 1-631-485-4226; 16314854226
- info@bocsci.com
Haoyuan Chemexpress Co., Ltd.
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- 021-58950125
- info@chemexpress.com
MedChemexpress LLC
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- 021-58955995
- sales@medchemexpress.cn