ETHYL 1H-INDAZOLE-5-CARBOXYLATE Chemical Properties

Melting point:

122-124℃

Boiling point:

353.9±15.0 °C(Predicted)

Density 

1.272±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

pka

12.81±0.40(Predicted)

color 

White to Yellow to Orange

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

29339900

ETHYL 1H-INDAZOLE-5-CARBOXYLATE Usage And Synthesis

Synthesis

Ethyl 1-acetyl-1H-indazole-5-carboxylate was used as a raw material, which was dissolved in a mixed solvent consisting of concentrated hydrochloric acid (15 mL), water (15 mL) and ethanol (30 mL), and the reaction was stirred for 4 hours at room temperature. Upon completion of the reaction, the pH of the reaction mixture was adjusted to slightly basic with 25% ammonia. Subsequently, the alkalized mixture was extracted with chloroform. The organic phases were combined and purified by hexane crystallization. After completion of crystallization, the resulting crystals were collected by filtration and dried to give the final ethyl 5-indazolecarboxylate (6.45 g, 48% yield) as a light brown powder.

References

[1] Journal of Medicinal Chemistry, 2000, vol. 43, # 1, p. 41 - 58
[2] Patent: US2013/79306, 2013, A1. Location in patent: Paragraph 0286

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