XY1 Chemical Properties

Boiling point:

514.8±42.0 °C(Predicted)

Density 

1.284±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

DMF: 10 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml

form 

A crystalline solid

pka

12.62±0.46(Predicted)

color 

White to off-white

XY1 Usage And Synthesis

Description

Protein arginine N-methyltransferase 3 (PRMT3, ) is a predominantly cytoplasmic enzyme that is constitutively expressed. SGC707 is a potent, selective allosteric inhibitor of PRMT3 (IC₅₀ = 50 nM). It inhibits the methylation of histones in cells with an IC₅₀ value below 1 μM. XY1 is a close analog of SGC707 that is completely inactive against PRMT3 at concentrations as high as 100 μM. It is intended to be used as a negative control for SGC707 in studies involving PRMT3 action. See the Structural Genomics Consortium (SGC) website for more information.

Uses

XY1 acts as a close analog of SGC707 that is completely inactive against PRMT3, inhibiting the methylation of histones in cells.

storage

Store at +4°C

References

[1] J TANG. PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation.[J]. The Journal of Biological Chemistry, 1998, 273 27: 16935-16945. DOI: 10.1074/jbc.273.27.16935
[2] WOLF S S. The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans.[J]. Cellular and Molecular Life Sciences, 2009, 66 13: 2109-2121. DOI: 10.1007/s00018-009-0010-x
[3] DR. H. üMIT KANISKAN. A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)[J]. Angewandte Chemie International Edition, 2015, 54 17: 5166-5170. DOI: 10.1002/anie.201412154

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