LEVOCABASTINE Chemical Properties

Boiling point:

589.9±50.0 °C(Predicted)

Density 

1.23

pka

3.57±0.40(Predicted)

LEVOCABASTINE Usage And Synthesis

Originator

Livostin,Janssen-Cilag,Belgium

Uses

Anti histaminic.

Definition

ChEBI: Levocabastine is a member of piperidines.

Manufacturing Process

4-Cyano-4-(4-fluorophenyl)-heptanedioic acid diethyl ester is obtained by addition of ethyl acrylate to the anion from p-fluorophenylacetonitrile. By base catalyzed cyclization of these diester (sodium methoxide, 60°C, xylene) is synthesized an intermediate that after decarboethoxylation gives 1-(4- fluorophenyl)-4-oxycyclohexanecarbonitrile. By condensation of 3-methyl-5- phenylpiperidine-4-carboxylic acid benzyl ester and 1-(4-fluorophenyl)-4- oxycyclohexanecarbonitrile under reductive hydrogenation conditions (palladium-on-charcoal catalyst, 50°C, in ethanol) is prepared benzyl ester 4- piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl- 4-phenyl-, (3S-(1(cis),3α,4β))-. The benzyl protecting group is then removed by hydrogenation method and 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4- fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3α,4β))- obtained is transformed into 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl) cyclohexyl)-3-methyl-4-phenyl-, hydrochloride, (3S-(1(cis), 3α,4β))- (Levocabastine hydrochloride)

brand name

Livostin (Novartis).

Therapeutic Function

Antihistaminic

LEVOCABASTINE(79516-68-0)Related Product Information

• Antazoline
• Pirenoxine
• 2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE
• 1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid monohydrochloride
• 1-(4-FLUOROPHENYL)CYCLOHEXANECARBONITRILE
• 1-Phenyl-1-cyclohexanecarbonitrile
• 4-Fluorophenylacetonitrile
• 4-Phenylcyclohexanamine
• LEVOCABASTINE
• LEVOCABASTINE IMPURITY D
• 4-Piperidinecarboxylicacid,1-(1-methylethyl)-(9CI)
• 4-Piperidinemethanol,1-(1-methylethyl)-(9CI)
• (αS)-α-Isopropylbenzeneacetic acid
• PETHIDINIC ACID
• 5-Piperidinovaleronitrile
• Cabastine
• 4-phenyl-1-(4-phenylbutyl)piperidine