Cariprazine D8 Chemical Properties

Melting point:

>198°C (dec.)

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

Off-White to Pale Beige

Cariprazine D8 Usage And Synthesis

Uses

Cariprazine-d8 is a deuterium labeled Cariprazine. Cariprazine is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).

IC 50

D₃ Receptor

References

[1] Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl). 2011 Dec;218(3):579-8. DOI:10.1007/s00213-011-2343-z

Cariprazine D8(1308278-50-3)Related Product Information

• Cariprazine
• Nsc175383
• Cariprazine intermediate 2
• Desmethyl Cariprazine
• Piperazine, 1-(2-chloroethyl)-4-(2,3-dichlorophenyl)-
• Urea, N,N'-bis[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-
• Urea, N,N-dimethyl-N'-[trans-4-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]cyclohexyl]-
• ethyl dimethylcarbamate
• 3,3-dimethyl-1-[(1r,4r)-4-(2-hydroxyethyl)cyclohexyl]urea
• Cyclohexaneethanol, 4-amino-, hydrochloride (1:1), trans-