m-PEG3-Sulfone-PEG2-OH Chemical Properties

Boiling point:

498.2±45.0 °C(Predicted)

Density 

1.173±0.06 g/cm3(Predicted)

pka

14.36±0.10(Predicted)

m-PEG3-Sulfone-PEG2-OH Usage And Synthesis

Description

m-PEG3-Sulfone-PEG2-OH is a PEG linker containing sulfone and hydroxyl moieties. The sulfone can react with thiol groups of proteins. The hydroxyl group can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Uses

m-PEG3-Sulfone-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

m-PEG3-Sulfone-PEG2-OH(1919045-00-3)Related Product Information

• m-PEG3-Mal
• m-PEG3-Sulfone-PEG3-azide
• Diethylene Glycol 2-Bromoethyl Methyl Ether
• m-PEG3-Sulfone-PEG3-acid
• m-PEG3-NHS ester
• m-PEG3-Sulfone-PEG4-propargyl
• m-PEG3-aldehyde
• 2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol
• 2-[2-(2-METHOXYETHOXY)ETHOXY]ACETIC ACID
• m-PEG3-Sulfone-PEG3-t-butyl ester
• m-PEG3-Tos