m-PEG3-Sulfone-PEG4-propargyl Chemical Properties

Boiling point:

536.0±50.0 °C(Predicted)

Density 

1.137±0.06 g/cm3(Predicted)

m-PEG3-Sulfone-PEG4-propargyl Usage And Synthesis

Description

m-PEG3-Sulfone-PEG4-propargyl is a sulfonated PEG linker containing a propargyl group. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

m-PEG3-Sulfone-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG3-Sulfone-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

m-PEG3-Sulfone-PEG4-propargyl(2055041-02-4)Related Product Information

• m-PEG3-Mal
• m-PEG3-Sulfone-PEG3-azide
• Diethylene Glycol 2-Bromoethyl Methyl Ether
• m-PEG3-Sulfone-PEG3-acid
• m-PEG3-NHS ester
• m-PEG3-aldehyde
• m-PEG3-Sulfone-PEG2-OH
• 2-[2-(2-methoxyethoxy)ethoxy]-ethanethiol
• 2-[2-(2-METHOXYETHOXY)ETHOXY]ACETIC ACID
• m-PEG3-Sulfone-PEG3-t-butyl ester
• m-PEG3-Tos