Basic information Safety Supplier Related

Pomalidomide-d5

Basic information Safety Supplier Related

Pomalidomide-d5 Basic information

Product Name:
Pomalidomide-d5
Synonyms:
  • 4-Amino-2-(2,6-dioxopiperidin-3-yl-3,4,4,5,5-d5)isoindoline-1,3-dione
  • Pomalidomide-d5
CAS:
1377838-49-7
MF:
C13H11N3O4
MW:
273.25
Mol File:
1377838-49-7.mol
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Pomalidomide-d5 Chemical Properties

storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml,DMSO: 15 mg/ml
form 
A solid
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Pomalidomide-d5 Usage And Synthesis

Description

Pomalidomide-d5 is intended for use as an internal standard for the quantification of pomalidomide by GC- or LC-MS. Pomalidomide is an analog of thalidomide that inhibits the E3 ligase protein cereblon (CRBN) with an IC50 value of approximately 3 μM for the human recombinant CRBN-DNA damage binding protein-1 (CRBN-DDB1) complex. It inhibits autoubiquitination of CRBN in HEK293T cells expressing CRBN but not those expressing a thalidomide-binding defective CRBN mutation. It inhibits proliferation of U266 myeloma cells when used at concentrations ranging from 0.1 to 10 μM. Pomalidomide also has antiangiogenic and immunomodulatory effects against myeloma cells, modulating cell adhesion, decreasing production of key pro-survival cytokines, including TNF-α, and triggering the activation of caspase-8. Pomalidomide (3 mg/kg per day), in combination with dexamethasone, reduces tumor growth in a H929 R10-1 lenalidomide-resistant mouse xenograft model. Formulations containing pomalidomide have been used in the treatment of multiple myeloma.

Uses

Pomalidomide-d5 is the labeled analogue of Pomalidomide (P688200), a thalidomide derivative, a potent inhibitor of TNF-α production. It is an antiinflammatory and antitumor agent used in the treatment of multiple myeloma.

Pomalidomide-d5Supplier

Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 13675144456
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Changzhou Xianglong Pharmaceutical Technology Co., LTD
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18661161657
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Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627
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TLC Pharmaceutical Standards Ltd.
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18012923235
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chinasales04@tlcstandards.com.cn