3-BROMO-2,5-DICHLOROPYRIDINE Chemical Properties

Melting point:

38-40°C

Boiling point:

195-198C

Density 

1,199g/cm

refractive index 

1,424-1,426

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

soluble in Methanol

form 

powder to crystal

pka

-3.02±0.10(Predicted)

color 

Light orange to Yellow to Green

CAS DataBase Reference

138006-41-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

36/37/38-41-37/38-25

Safety Statements 

26-45-39

RIDADR 

UN2811

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

2933399990

3-BROMO-2,5-DICHLOROPYRIDINE Usage And Synthesis

Synthesis

Example 3 Synthesis of 3-bromo-2,5-dichloropyridine: To a solution of 3-bromo-5-chloropyridin-2-one (84.3 g, 0.404 mol) in N,N-dimethylformamide (DMF, 100 mL) was slowly added phosphorus oxychloride (POCl3, 56.5 mL, 0.61 mol) through a dropping funnel at room temperature, and the process of dropping was continued for 3 hours. Subsequently, the resulting black solution was heated to 70 °C and the reaction was stirred at this temperature for 3 days. Upon completion of the reaction, the mixture was cooled to room temperature and carefully poured into 1 L of ice water. The precipitated solid was collected by filtration and dried in a vacuum oven to afford 81.76 g (89% yield) of the target product 3-bromo-2,5-dichloropyridine as a white solid with a melting point of 39-41 °C. The product was confirmed by infrared spectroscopy (IR, CHCl3), and the main absorption peaks were located at 3867, 3663, 2989, 2734, 1812, 1606, 1547, 1400, 1366, 1230, 1155, 1129, 1074, 1027, 894, 658, and 563 cm-1. Nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 300 MHz, CDCl3) showed signals at δ 8.0 (d, 1H, J = 2.2 Hz) and 8.35 (d, 1H, J = 2.2 Hz). Nuclear magnetic resonance carbon spectra (13C NMR, CDCl3) showed signals at δ 120.43, 130.74, 141.46, 146.64, and 148.99. The high resolution mass spectrum measured the molecular weight of 224.8764, which is consistent with the calculated value of C5H2NBrCl2 (224.8748).

References

[1] Patent: US5068333, 1991, A

3-BROMO-2,5-DICHLOROPYRIDINE(138006-41-4)Related Product Information

• 4-Chloro-3-nitropyridine
• 3-BROMO-5-CHLORO-2-METHOXY-PYRIDINE
• 2,6-Dichloropyridin-3-amine
• 5-Amino-2,3-dichloropyridine
• 2,5-Dichloropyridine
• 4-BROMO-3,5-DICHLOROPYRIDINE
• 2-BROMO-3,5-DICHLOROPYRIDINE
• 5-Bromo-2,4-dichloropyridine
• 2-BROMO-3,5-DICHLOROPYRIDINE-4-CARBOXYLIC ACID
• 3-BROMO-2,6-DICHLOROPYRIDINE
• 5-BROMO-2,3-DICHLOROPYRIDINE
• Pyridine, 4-bromo-2,5-dichloro-
• 3-Bromo-5-chloropyridine
• 3-Bromo-2-chloropyridine
• 3-BROMO-2,5-DICHLOROPYRIDINE
• 4-bromo-2,6-dichloropyridine
• 3-Amino-6-bromo-2,4-dichloropyridine
• 5-BROMO-2,3-DICHLOROPYRIDINE 5-BROMO-2,3-DICHLORO-PYRIDINE