2,5-Dichloropyridine Chemical Properties

Melting point:

59-62 °C (lit.)

Boiling point:

190-191 °C

Density 

1.5159 (rough estimate)

refractive index 

1.5500 (estimate)

Flash point:

112 °C

storage temp. 

Inert atmosphere,Room Temperature

pka

-2.25±0.10(Predicted)

form 

Crystalline Solid

color 

White to slightly yellow

Water Solubility 

insoluble

BRN 

108886

CAS DataBase Reference

16110-09-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-37/39-36

RIDADR 

UN2811

WGK Germany 

3

RTECS 

US8225000

Hazard Note 

Harmful

HazardClass 

IRRITANT

HazardClass 

6.1

HS Code 

29333990

MSDS

• Language:English Provider:2,5-Dichloropyridine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,5-Dichloropyridine Usage And Synthesis

Uses

2,5-Dichloropyridine is a reagent used in chemical synthesis. It has been used to synthesize 4-benzodiazepine-2,5 diones as Hdm2 antagonists and inhibitors of ERK protein kinase.

Chemical Properties

white to slightly yellow crystalline solid

Uses

2,5-Dichloropyridine was used in the synthesis of 6-halo-pyridin-3-yl boronic acids and esters. It undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst.

Synthesis Reference(s)

Synthetic Communications, 20, p. 2971, 1990 DOI: 10.1080/00397919008051514

General Description

2,5-Dichloropyridine undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst.

2,5-Dichloropyridine(16110-09-1)Related Product Information

• 5-Amino-2-methylpyridine
• 2-Chloro-5-chloromethylpyridine
• 2-(Hydroxymethyl)pyridine
• 2,6-Lutidine
• 1,2-Dichloroethane
• 2,5-Dimethylpyridine
• 2,3-DICHLOROPYRIDINE
• Methyl 2,3,5,6-tetrachloro-4-pyridyl sulfone
• Triclopyr
• Picloram
• Chlorpyrifos
• 2,3,5,6-Tetrachloropyridine
• 2,6-Dichloropyridine
• Dichloropyridine,98%
• 2,3,5,6-Tetrachloropyridine-4-thiol
• Pentachloropyridine
• 2,3,5-Trichloropyridine
• Clopyralid