Methyl 2,3,5,6-tetrachloro-4-pyridyl sulfone Chemical Properties

Melting point:

148 °C

Boiling point:

451.1±45.0 °C(Predicted)

Density 

1.712±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder to crystal

pka

-7.71±0.50(Predicted)

color 

White to Light yellow to Light orange

EPA Substance Registry System

2,3,5,6-Tetrachloro-4-(methylsulfonyl)pyridine (13108-52-6)

Safety Information

Hazard Codes 

Xn

Risk Statements 

21/22-36-43

Safety Statements 

26-28

HS Code 

2933.39.2100

Methyl 2,3,5,6-tetrachloro-4-pyridyl sulfone Usage And Synthesis

Chemical Properties

Yellow solid

Uses

2,3,5,6-Tetrachloro-4-(methylsulfonyl)pyridine is an antifouling biocide.

Synthesis

General procedure for the synthesis of 2,3,5,6-tetrachloro-4-(methylsulfonyl)pyridine from 2,3,5,6-tetrachloro-4-(methylsulfonyl)pyridine: 2,3,5,6-tetrachloro-4-mercapto-pyridine (10 g, 38.0 mmol) was dissolved in dichloromethane (DCM) (80 mL), and cooled in an ice water bath. M-chloroperoxybenzoic acid (14.4 g) was added in three batches over 15 minutes, with each batch evenly spaced. The reaction solution was stirred and reacted at room temperature for 3 h. The complete reaction of the raw material was confirmed by GC assay. After the reaction was completed, the reaction solution was washed with saturated sodium carbonate solution (2×20 mL), the organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to obtain the crude product. To the crude product was added ethanol (5 mL), filtered and dried to obtain 2,3,5,6-tetrachloro-4-(methylsulfonyl)pyridine (10.8 g, 96% yield).

References

[1] Patent: CN106478494, 2017, A. Location in patent: Paragraph 0019; 0022; 0025; 0028; 0031; 0035; 0040; 0041

Methyl 2,3,5,6-tetrachloro-4-pyridyl sulfone (13108-52-6)Related Product Information

• Pyridine
• Tribenuron methyl
• Methyl acetate
• Chlorosulfonyl isocyanate
• METSULFURON METHYL
• Sulfasalazine
• Methyl salicylate
• Kresoxim-methyl
• Thiophanate-methyl
• Methyl
• 2,3,6-Trichloropyridine
• 2,3,5-Trichloropyridine
• 2,3,5,6-Tetrachloropyridine-4-thiol
• 4-Mercaptopyridine
• 2,3-Dichloropyridine
• 2,3,5,6-Tetrachloropyridine
• 2-CHLORO-4-(METHYLTHIO)-PYRIDINE
• Methyl bromide