2,3-Dichloropyridine Chemical Properties

Melting point:

64-67 °C (lit.)

Boiling point:

242.42°C (rough estimate)

Density 

1.5159 (rough estimate)

refractive index 

1.5500 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

form 

Crystalline Powder

pka

-0.63±0.10(Predicted)

color 

White to slightly beige

Water Solubility 

slightly soluble

BRN 

109811

InChI

InChI=1S/C5H3Cl2N/c6-4-2-1-3-8-5(4)7/h1-3H

InChIKey

MAKFMOSBBNKPMS-UHFFFAOYSA-N

SMILES

C1(Cl)=NC=CC=C1Cl

CAS DataBase Reference

2402-77-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36-37/39

RIDADR 

UN2811

WGK Germany 

3

RTECS 

US8050000

Hazard Note 

Irritant

HazardClass 

6.1

HS Code 

29333999

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:2,3-Dichloropyridine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,3-Dichloropyridine Usage And Synthesis

Chemical Properties

White to slightly beige crystalline powder

Uses

2,3-Dichloropyridine is used as a reagent for the preparation of substituted 3-(5-membered heterocycle-carboxamido)pyridine derivatives for treatment of autoimmune and inflammatory diseases. Also in the synthesis, crystal structure and biological activity of novel anthranilic Diamide insecticide with propargyl ether.

Application

As an important fine chemical intermediate, 2,3-Dichloropyridine has been usually applied to the field of pesticide and medicine research.

Reactions

2,3-Dichloropyridine reacts with strong oxidizing agents and mineral acids.

Hazard

2,3-Dichloropyridine is irritating to skin and eyes. It is also irritation to tissues of the mucous membranes and upper respiratory tract.

Synthesis

2,3-dichloropyridine is synthesized from 2-chloronicotinic acid via amidation, Hofmann degradation, diazotization and Sandmeyer reaction.

Structure and conformation

The complete mol-ecule of 2,3-Dichloropyridine, C5H3Cl2N, is generated by crystallographic twofold symmetry, which forces the pyridine N atom and the opposite C—H group to be statistically disordered. In the crystal, weak aromatic π–π stacking [centroid–centroid separation = 3.805 (4)Å and slippage = 1.704Å] leads to [100] stacks of mol-ecules. Short Cl···Cl contacts [3.334 (3)Å] are also observed. Colourless prisms were grown from ethanol.

2,3-Dichloropyridine(2402-77-9)Related Product Information

• 3-Aminopyridine
• 3-Hydroxypyridine
• Dichloroethane
• 2-Chloro-3-hydroxypyridine
• 2,5-Dichloropyridine
• 1,3-Dichloropropene
• 2-Chloro-5-chloromethylpyridine
• Clopyralid
• Dichloropyridine,98%
• 2,3,5,6-Tetrachloropyridine-4-thiol
• Pentachloropyridine
• 5,6-Dichloronicotinic acid
• Picloram
• 2,3,5-Trichloropyridine
• 3,4,5,6-Tetrachloropyridine-2-carbonitrile
• Triclopyr
• 2,3-Dichloro-5-(trichloromethyl)pyridine
• Methyl 2,3,5,6-tetrachloro-4-pyridyl sulfone