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PICROTIN

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PICROTIN Basic information

Product Name:
PICROTIN
Synonyms:
  • PICROTIN
  • (1aR,8aS,9S)-1aβ,2,2a,6,6aα,8b-Hexahydro-2aα-hydroxy-9-(1-hydroxy-1-methylethyl)-8bα-methyl-3α,6α-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione
  • (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-Hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione
  • Picrotin CRS
  • 3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-
CAS:
21416-53-5
MF:
C15H18O7
MW:
310.3
Product Categories:
  • Plant Oils, Toxins, Phenolic Acids & Derivatives
Mol File:
21416-53-5.mol
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PICROTIN Chemical Properties

Melting point:
256-258°C
alpha 
D -64.7° (c = 2.31 in abs alc)
Boiling point:
595.8±50.0 °C(Predicted)
Density 
1.59
storage temp. 
2-8°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml
pka
13.28±0.60(Predicted)
form 
Solid
color 
White to off-white
EPA Substance Registry System
Picrotin (21416-53-5)
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Safety Information

WGK Germany 
3
RTECS 
TJ8800000
Toxicity
LD50 i.p. in mice: 135 mg/kg (Jarboe)
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PICROTIN Usage And Synthesis

Description

Picrotin is a natural picrotoxane that antagonizes glycine receptors (GlyRs; IC50s = 57 and 117 μM for α1 and α2 homodimeric GlyRs, respectively). It also inhibits α3 homodimeric GlyRs. Picrotin is inactive in inhibiting γ-aminobutyric acid (GABA) type A and type C receptors. Picrotin occurs in the natural plant-derived poison picrotoxin , equimolar with picrotoxinin.

Uses

GABAa receptor antagonist

Definition

ChEBI: Picrotin is an organic heteropentacyclic compound that is picrotoxinin in which the olefinic double bond has undergone addition of water to give the corresponding tertiary alcohol. It is the less toxic component of picrotoxin, lacking GABA activity. It has a role as a plant metabolite. It is an organic heteropentacyclic compound, an epoxide, a tertiary alcohol, a gamma-lactone, a diol and a picrotoxane sesquiterpenoid. It is functionally related to a picrotoxinin.

PICROTINSupplier

Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Email
market03@meryer.com
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Email
climaxbiotech@gmail.com
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Email
tauto@tautobiotech.com
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Email
info@tsbiochem.com
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Email
3003855609@qq.com
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