2,3-Dihydro-1-benzofuran-5-sulfonyl chloride Chemical Properties

Melting point:

84 °C

Boiling point:

339.6±31.0 °C(Predicted)

Density 

1.495±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

soluble in Toluene

form 

powder to crystal

color 

White to Light yellow to Green

CAS DataBase Reference

115010-11-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

3261

Hazard Note 

Corrosive

HazardClass 

IRRITANT

HazardClass 

8

PackingGroup 

Ⅲ

HS Code 

2932990090

2,3-Dihydro-1-benzofuran-5-sulfonyl chloride Usage And Synthesis

Synthesis

Under argon protection, 3.56 g (29.6 mmol) of 2,3-dihydrobenzofuran was added to a 12 mL slurry of 1,2-dichloroethane containing 5.44 g (35.5 mmol) of sulfur trioxide-N,N-dimethylformamide complex. The reaction system was heated to 85 °C, maintained for 1 h and cooled to room temperature. Subsequently, thionyl chloride (2.6 mL, 35.5 mmol, 1.2 eq.) was added slowly and the temperature was gradually increased to 75 °C over 1 hour. After completion of the reaction, the mixture was cooled to room temperature and extracted by adding 100 mL of dichloromethane and 100 mL of water. The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 6.56 g (100% yield) of 2,3-dihydrobenzofuran-5-sulfonyl chloride as a tan oil (TLC Rf value, chloroform/hexane=1/1).

References

[1] Patent: US2005/267074, 2005, A1. Location in patent: Page/Page column 25; 44
[2] Patent: US2008/227744, 2008, A1. Location in patent: Page/Page column 12-13
[3] Patent: US6506754, 2003, B1
[4] Patent: US5387681, 1995, A
[5] Patent: WO2005/58858, 2005, A1. Location in patent: Page/Page column 129

2,3-Dihydro-1-benzofuran-5-sulfonyl chloride(115010-11-2)Related Product Information

• 2,3-Dihydrobenzofuran
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• Ammonium chloride
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